PDB
9JCO
Resolution
2.4 Å
Released
July 9, 2025
Receptor
GPR4
Class
A
Species
Homo sapiens
Ligand
Function
Lysophosphatidylcholine (LPC)
PAM
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Lysophosphatidylcholine (LPC) Y55 2.42x42 TM2 Van der Waals
Lysophosphatidylcholine (LPC) C109 3.44x44 TM3 Van der Waals
Lysophosphatidylcholine (LPC) C110 3.45x45 TM3 Van der Waals
Lysophosphatidylcholine (LPC) V113 3.48x48 TM3 hydrophobic
Lysophosphatidylcholine (LPC) D114 3.49x49 TM3 hydrophobic
Lysophosphatidylcholine (LPC) L117 3.52x52 TM3 Van der Waals
Lysophosphatidylcholine (LPC) V137 4.45x45 TM4 Van der Waals
Lysophosphatidylcholine (LPC) T144 4.52x52 TM4 Van der Waals
Lysophosphatidylcholine (LPC) E145 4.53x53 TM4 polar (charge-charge)
Lysophosphatidylcholine (LPC) V188 5.45x46 TM5 Van der Waals
Lysophosphatidylcholine (LPC) F192 5.49x49 TM5 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R ICL1ECL1 D N W I H ECL1ICL2 P L R F A R L R ICL2ECL2 D E L F R D R Y N H T F C F E K F P M ECL2ICL3 S V S T ICL3ECL3 W D ECL3N-term M G N H T W E G C H V N-termC-term F L A S D K P Q E M A N A S L T L E T P L T S K R N S T A K A M T G S W A A T P P S Q G D Q V Q L K M L P P A Q C-term D S R V D H L F P P S L Y I F V I G V G L P T N C L A L W A A Y R Q V Q Q N E L G V Y L M N L S I A D L L Y I C T L P L W V D Y F L H H G P G S C K L F G F I F Y T N I Y I S I A F L C C I S V D R Y L A V A H R V K T A V A V S S V V W A T E L G A N S A P L F H E G W V A W M N L Y R V F V G F L F P W A L M L L S Y R G I L R A V R G E R Q E K A K I K R L A L S L I A I V L V C F A P Y H V L L L S R S A I Y L G R P C G F E E R V F S A Y H S S L A F T S L N C V A D P I L Y C L V N E G V A K L L R A R S D A L H N
Helix box plot — Download: PNG | SVG C N T P L G V G I V F I Y L S P P F L H 1 M N L S I A D L L Y I C T L P L W V D Y 2 C C L F A I S I Y I N T Y F I F G F L K 3 A V A V S S V V W A T E L G A N S A P L 4 Y S L L M L A W P F L F G V F V R Y L N M 5 L S L I A I V L V C F A P Y H V L L L S 6 I P D A V C N L S T F A L S S H Y A S 7

GPCRdb(A)
GPCRdb(A)
GPR4
TM2
2x42 2.42x42 Y55
TM3
3x44 3.44x44 C109
3x45 3.45x45 C110
3x48 3.48x48 V113
3x49 3.49x49 D114
3x52 3.52x52 L117
TM4
4x45 4.45x45 V137
4x52 4.52x52 T144
4x53 4.53x53 E145
TM5
5x46 5.45x46 V188
5x49 5.49x49 F192