PDB
9JFU
Resolution
3.2 Å
Released
April 23, 2025
Receptor
GPR4
Class
A
Species
Homo sapiens
Ligand
Function
NE 52-QQ57
Antagonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
NE 52-QQ57 Y24 1.39x39 TM1 hydrophobic
NE 52-QQ57 L70 2.57x57 TM2 hydrophobic
NE 52-QQ57 W73 2.60x60 TM2 aromatic (face-to-face)
NE 52-QQ57 W73 2.60x60 TM2 aromatic (edge-to-face)
NE 52-QQ57 W73 2.60x60 TM2 hydrophobic
NE 52-QQ57 Y76 2.63x63 TM2 Van der Waals
NE 52-QQ57 F77 2.64x64 TM2 hydrophobic
NE 52-QQ57 D81 ECL1 polar (charge-charge)
NE 52-QQ57 F93 3.28x28 TM3 Van der Waals
NE 52-QQ57 F97 3.32x32 TM3 Van der Waals
NE 52-QQ57 F167 ECL2 Van der Waals
NE 52-QQ57 C168 45.50x50 ECL2 Van der Waals
NE 52-QQ57 F169 45.51x51 ECL2 hydrophobic
NE 52-QQ57 H381 7.36x35 TM7 aromatic (edge-to-face)
NE 52-QQ57 L384 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R ICL1ECL1 D N W I H ECL1ICL2 P L R F A R L R ICL2ECL2 D E L F R D R Y N H T F C F E K F P M ECL2ICL3 S V S T ICL3ECL3 W D ECL3N-term M G N H T W E G C H V N-termC-term F L A S D K P Q E M A N A S L T L E T P L T S K R N S T A K A M T G S W A A T P P S Q G D Q V Q L K M L P P A Q C-term D S R V D H L F P P S L Y I F V I G V G L P T N C L A L W A A Y R Q V Q Q N E L G V Y L M N L S I A D L L Y I C T L P L W V D Y F L H H G P G S C K L F G F I F Y T N I Y I S I A F L C C I S V D R Y L A V A H R V K T A V A V S S V V W A T E L G A N S A P L F H E G W V A W M N L Y R V F V G F L F P W A L M L L S Y R G I L R A V R G E R Q E K A K I K R L A L S L I A I V L V C F A P Y H V L L L S R S A I Y L G R P C G F E E R V F S A Y H S S L A F T S L N C V A D P I L Y C L V N E G V A K L L R A R S D A L H N
Helix box plot — Download: PNG | SVG C N T P L G V G I V F I Y L S P P F L H 1 M N L S I A D L L Y I C T L P L W V D Y 2 C C L F A I S I Y I N T Y F I F G F L K 3 A V A V S S V V W A T E L G A N S A P L 4 Y S L L M L A W P F L F G V F V R Y L N M 5 L S L I A I V L V C F A P Y H V L L L S 6 I P D A V C N L S T F A L S S H Y A S 7

GPCRdb(A)
GPCRdb(A)
GPR4
TM1
1x39 1.39x39 Y24
TM2
2x57 2.57x57 L70
2x60 2.60x60 W73
2x63 2.63x63 Y76
2x64 2.64x64 F77
TM3
3x28 3.28x28 F93
3x32 3.32x32 F97
ECL2
45x50 45.50x50 C168
45x51 45.51x51 F169
TM7
7x35 7.36x35 H269
7x38 7.39x38 L272