PDB
9JH5
Resolution
2.8 Å
Released
April 23, 2025
Receptor
CysLT2
Class
A
Species
Homo sapiens
Ligand
Function
C16:0 ceramide
Agonist
Reference
10.1038/S41586-025-08792-8

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Ligand Amino Acid Generic Number Segment Interaction Type
C16:0 ceramide Y116 3.30x30 TM3 Van der Waals
C16:0 ceramide Y119 3.33x33 TM3 Van der Waals
C16:0 ceramide V120 3.34x34 TM3 Van der Waals
C16:0 ceramide Y123 3.37x37 TM3 polar (hydrogen bond)
C16:0 ceramide Y123 3.37x37 TM3 hydrophobic
C16:0 ceramide Y127 3.41x41 TM3 hydrophobic
C16:0 ceramide L165 4.52x52 TM4 Van der Waals
C16:0 ceramide I166 4.53x53 TM4 hydrophobic
C16:0 ceramide S169 4.56x56 TM4 Van der Waals
C16:0 ceramide S170 4.57x57 TM4 Van der Waals
C16:0 ceramide I195 ECL2 hydrophobic
C16:0 ceramide A196 ECL2 Van der Waals
C16:0 ceramide L198 5.35x36 TM5 hydrophobic
C16:0 ceramide M201 5.38x39 TM5 Van der Waals
C16:0 ceramide N202 5.39x40 TM5 hydrophobic
C16:0 ceramide A205 5.42x43 TM5 Van der Waals
C16:0 ceramide V208 5.45x46 TM5 Van der Waals
C16:0 ceramide R267 6.55x55 TM6 Van der Waals
C16:0 ceramide T268 6.56x56 TM6 Van der Waals
C16:0 ceramide H270 6.58x58 TM6 Van der Waals
C16:0 ceramide L271 6.59x59 TM6 hydrophobic
C16:0 ceramide K275 ECL3 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 Y K K S ICL1ECL1 S N W I F ECL1ICL2 P F R L L H V T ICL2ECL2 G S E Q N G S V T S C L E L N L Y K ECL2ICL3 E V P E ICL3ECL3 K V G L C ECL3N-term M E R K F M S L Q P S I S V S E M E P N G T F S N N N S R N N-termC-term G H P Q K A K T K C V F P V S V W L R K E T R V C-term C T I E N F K R E F F P I V Y L I I F F W G V L G N G L S I Y V F L Q P T S V N V F M L N L A I S D L L F I S T L P F R A D Y Y L R G G D L A C R I M S Y S L Y V N M Y S S I Y F L T V L S V V R F L A M V H S I R S A W I L C G I I W I L I M A S S I M L L D S I A K L Q T M N Y I A L V V G C L L P F F T L S I C Y L L I I R V L L K V S G L R V S H R K A L T T I I I T L I I F F L C F L P Y H T L R T V H L T T W K D R L H K A L V I T L A L A A A N A C F N P L L Y Y F A G E N L K S F K D R A L R K
Helix box plot — Download: PNG | SVG G N G L V G W F F I I L Y V I P F F E R 1 L N L A I S D L L F I S T L P F R A D Y 2 V T L F Y I S S Y M N V Y L S Y S M I R 3 A W I L C G I I W I L I M A S S I M L 4 Y C I S L T F F P L L C G V V L A I Y N M 5 I I I T L I I F L F C F L P Y H T L R T V 6 L P N F C A N A A A L A L T I V L A K 7

GPCRdb(A)
GPCRdb(A)
CysLT2 receptor
TM3
3x30 3.30x30 Y116
3x33 3.33x33 Y119
3x34 3.34x34 V120
3x37 3.37x37 Y123
3x41 3.41x41 Y127
TM4
4x52 4.52x52 L165
4x53 4.53x53 I166
4x56 4.56x56 S169
4x57 4.57x57 S170
TM5
5x36 5.35x36 L198
5x39 5.38x39 M201
5x40 5.39x40 N202
5x43 5.42x43 A205
5x46 5.45x46 V208
TM6
6x55 6.55x55 R267
6x56 6.56x56 T268
6x58 6.58x58 H270
6x59 6.59x59 L271