PDB
9JH6
Resolution
2.9 Å
Released
April 30, 2025
Receptor
CysLT2
Class
A
Species
Homo sapiens
Ligand
Function
Cer(d18:0/20:0)
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
Cer(d18:0/20:0) F41 1.35x35 TM1 hydrophobic
Cer(d18:0/20:0) R94 2.60x60 TM2 hydrophobic
Cer(d18:0/20:0) Y98 2.64x64 TM2 Van der Waals
Cer(d18:0/20:0) L118 3.32x32 TM3 hydrophobic
Cer(d18:0/20:0) Y119 3.33x33 TM3 Van der Waals
Cer(d18:0/20:0) Y123 3.37x37 TM3 hydrophobic
Cer(d18:0/20:0) Y127 3.41x41 TM3 hydrophobic
Cer(d18:0/20:0) L165 4.52x52 TM4 hydrophobic
Cer(d18:0/20:0) I166 4.53x53 TM4 hydrophobic
Cer(d18:0/20:0) S169 4.56x56 TM4 Van der Waals
Cer(d18:0/20:0) S170 4.57x57 TM4 Van der Waals
Cer(d18:0/20:0) L173 4.60x61 TM4 Van der Waals
Cer(d18:0/20:0) I195 ECL2 Van der Waals
Cer(d18:0/20:0) M201 5.38x39 TM5 Van der Waals
Cer(d18:0/20:0) N202 5.39x40 TM5 Van der Waals
Cer(d18:0/20:0) A205 5.42x43 TM5 hydrophobic
Cer(d18:0/20:0) V208 5.45x46 TM5 hydrophobic
Cer(d18:0/20:0) R267 6.55x55 TM6 hydrophobic
Cer(d18:0/20:0) L271 6.59x59 TM6 Van der Waals
Cer(d18:0/20:0) L287 7.35x34 TM7 hydrophobic
Cer(d18:0/20:0) L291 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 Y K K S ICL1ECL1 S N W I F ECL1ICL2 P F R L L H V T ICL2ECL2 G S E Q N G S V T S C L E L N L Y K ECL2ICL3 E V P E ICL3ECL3 K V G L C ECL3N-term M E R K F M S L Q P S I S V S E M E P N G T F S N N N S R N N-termC-term G H P Q K A K T K C V F P V S V W L R K E T R V C-term C T I E N F K R E F F P I V Y L I I F F W G V L G N G L S I Y V F L Q P T S V N V F M L N L A I S D L L F I S T L P F R A D Y Y L R G G D L A C R I M S Y S L Y V N M Y S S I Y F L T V L S V V R F L A M V H S I R S A W I L C G I I W I L I M A S S I M L L D S I A K L Q T M N Y I A L V V G C L L P F F T L S I C Y L L I I R V L L K V S G L R V S H R K A L T T I I I T L I I F F L C F L P Y H T L R T V H L T T W K D R L H K A L V I T L A L A A A N A C F N P L L Y Y F A G E N L K S F K D R A L R K
Helix box plot — Download: PNG | SVG G N G L V G W F F I I L Y V I P F F E R 1 L N L A I S D L L F I S T L P F R A D Y 2 V T L F Y I S S Y M N V Y L S Y S M I R 3 A W I L C G I I W I L I M A S S I M L 4 Y C I S L T F F P L L C G V V L A I Y N M 5 I I I T L I I F L F C F L P Y H T L R T V 6 L P N F C A N A A A L A L T I V L A K 7

GPCRdb(A)
GPCRdb(A)
CysLT2 receptor
TM1
1x35 1.35x35 F41
TM2
2x60 2.60x60 R94
2x64 2.64x64 Y98
TM3
3x32 3.32x32 L118
3x33 3.33x33 Y119
3x37 3.37x37 Y123
3x41 3.41x41 Y127
TM4
4x52 4.52x52 L165
4x53 4.53x53 I166
4x56 4.56x56 S169
4x57 4.57x57 S170
4x61 4.60x61 L173
TM5
5x39 5.38x39 M201
5x40 5.39x40 N202
5x43 5.42x43 A205
5x46 5.45x46 V208
TM6
6x55 6.55x55 R267
6x59 6.59x59 L271
TM7
7x34 7.35x34 L287
7x38 7.39x38 L291