PDB
9JKT
Resolution
3.1 Å
Released
Oct. 29, 2025
Receptor
HCA3
Class
A
Species
Homo sapiens
Ligand
Function
D-phenyllactic acid
Agonist
Reference
10.1371/JOURNAL.PBIO.3003480

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Ligand Amino Acid Generic Number Segment Interaction Type
D-phenyllactic acid V83 2.60x60 TM2 hydrophobic
D-phenyllactic acid Y86 2.63x63 TM2 hydrophobic
D-phenyllactic acid Y87 2.64x64 TM2 hydrophobic
D-phenyllactic acid V103 3.28x28 TM3 Van der Waals
D-phenyllactic acid L104 3.29x29 TM3 hydrophobic
D-phenyllactic acid F107 3.32x32 TM3 hydrophobic
D-phenyllactic acid A108 3.33x33 TM3 Van der Waals
D-phenyllactic acid R111 3.36x36 TM3 polar (charge-charge)
D-phenyllactic acid R111 3.36x36 TM3 polar (hydrogen bond)
D-phenyllactic acid C177 45.50x50 ECL2 Van der Waals
D-phenyllactic acid L280 7.39x38 TM7 Van der Waals
D-phenyllactic acid Y284 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 L K S W ICL1ECL1 R S D W K F ECL1ICL2 P H H A L N K I ICL2ECL2 L L I Q N G T A N V C I S F S I C H T F ECL2ICL3 Q M D R H A ICL3ECL3 G T Q N C E ECL3N-term M N R H H L Q D H F L E I D K K N C C V F R N-termC-term R C L Q R K I T G E P D N N R S T S V E L T G D P N K T R G A P E A L I A N S G E P W S P S Y L G P T S N N H S K K G H C H Q E P A S L E K Q L G C C I E C-term D D F I A K V L P P V L G L E F I F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F V M D Y Y V R G D I P C R L V L F M F A M N R Q G S I I F L T V V A V D R Y F R V V H S N W T A A I I S C L L W G I T V G L T V H L L K K K R W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R K I K R A I T F I M V V A I V F V I C F L P S V V V R I H I F W L L H T S V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F S T F P N F L I N
Helix box plot — Download: PNG | SVG G N G L L G F I F E L G L V P P L V K A 1 F N L A V A D F L L I I C L P F V M D Y 2 V T L F I I S G Q R N M A F M F L V L R 3 A A I I S C L L W G I T V G L T V H L L 4 S C F L I I G L P L F F E L L F M A E H W 5 M V V A I V F V I C F L P S V V V R I H 6 V P D L M S N M Y T F S L T I F F A L 7

GPCRdb(A)
GPCRdb(A)
HCA3 receptor
TM2
2x60 2.60x60 V83
2x63 2.63x63 Y86
2x64 2.64x64 Y87
TM3
3x28 3.28x28 V103
3x29 3.29x29 L104
3x32 3.32x32 F107
3x33 3.33x33 A108
3x36 3.36x36 R111
ECL2
45x50 45.50x50 C177
TM7
7x38 7.39x38 L280
7x42 7.43x42 Y284