PDB
9JQY
Resolution
2.9 Å
Released
Oct. 22, 2025
Receptor
EP4
Class
A
Species
Homo sapiens
Ligand
TG6-129
Function
Antagonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
TG6-129 M24 1.42x42 TM1 hydrophobic
TG6-129 V69 2.57x57 TM2 hydrophobic
TG6-129 Y77 2.65x65 TM2 polar (hydrogen bond)
TG6-129 Y77 2.65x65 TM2 polar (hydrogen bond)
TG6-129 R271 7.40x39 TM7 polar (charge-assisted hydrogen bond)
TG6-129 I272 7.41x40 TM7 hydrophobic
TG6-129 I272 7.41x40 TM7 Van der Waals
TG6-129 S274 7.43x42 TM7 Van der Waals
TG6-129 V275 7.44x43 TM7 Van der Waals
TG6-129 V275 7.44x43 TM7 hydrophobic

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ICL1 R K E Q K E ICL1ECL1 G Q W P G ECL1ICL2 A Y F Y S H Y V ICL2ECL2 L G S S R L Q Y P D T W C F I D W T T N ECL2ICL3 S L G T E Q H H A A A A A S V A S R G H P A A S P A L P R L S D F R R R R S F ICL3ECL3 Q P S L E R E V S K ECL3N-term M S T P G V N S S A S L S P D R L N-termC-term L F C R I G G S R R E R S G Q H C S D S Q R T S S A M S G H S R S F I S R E L K E I S S T S Q T L L P D L S L P D L S E N G L G G R N L L P G V P G M G L A Q E D T T S L R T L R I S E T S D S S Q G Q D S E S V L L V D E A G G S G R A G P A P K G S S L Q V T F P S E T L N L S E K C I C-term N S P V T I P A V M F I F G V V G N L V A I V V L C K S T T F Y T L V C G L A V T D L L G T L L V S P V T I A T Y M K G Q P L C E Y S T F I L L F F S L S G L S I I C A M S V E R Y L A I N H D K R L A G L T L F A V Y A S N V L F C A L P N M G V T A H A A Y S Y M Y A G F S S F L I L A T V L C N V L V C G A L L R M H R Q F M R R T R R I A G A E I Q M V I L L I A T S L V V L I C S I P L V V R V F V N Q L Y N P D L Q A I R I A S V N P I L D P W I Y I L L R K T A I E V L S K K I K C
Helix box plot — Download: PNG | SVG L N G V V G F I F M V A P I T V P S N 1 C G L A V T D L L G T L L V S P V T I A 2 A C I I S L G S L S F F L L I F T S Y E 3 A G L T L F A V Y A S N V L F C A L P N 4 N C L V T A L I L F S S F G A Y M Y S Y 5 I A T S L V V L I C S I P L V V R V F V 6 W P D L I P N V S A I R I A Q L D P N 7

GPCRdb(A)
GPCRdb(A)
EP4 receptor
TM1
1x42 1.42x42 M27
TM2
2x57 2.57x57 V72
2x65 2.65x65 Y80
TM7
7x39 7.40x39 R316
7x40 7.41x40 I317
7x42 7.43x42 S319
7x43 7.44x43 V320