PDB
9JQZ
Resolution
2.7 Å
Released
Oct. 22, 2025
Receptor
EP4
Class
A
Species
Homo sapiens
Ligand
Function
grapiprant
Antagonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
grapiprant I20 1.38x38 TM1 hydrophobic
grapiprant P21 1.39x39 TM1 Van der Waals
grapiprant M24 1.42x42 TM1 hydrophobic
grapiprant G65 2.53x53 TM2 Van der Waals
grapiprant V69 2.57x57 TM2 Van der Waals
grapiprant S70 2.58x58 TM2 Van der Waals
grapiprant T73 2.61x61 TM2 Van der Waals
grapiprant Y77 2.65x65 TM2 polar (hydrogen bond)
grapiprant L96 3.32x32 TM3 hydrophobic
grapiprant T165 ECL2 Van der Waals
grapiprant W166 ECL2 hydrophobic
grapiprant L267 7.36x35 TM7 Van der Waals
grapiprant I270 7.39x38 TM7 hydrophobic
grapiprant R271 7.40x39 TM7 hydrophobic
grapiprant R271 7.40x39 TM7 polar (hydrogen bond)
grapiprant R271 7.40x39 TM7 polar (charge-charge)
grapiprant A273 7.42x41 TM7 hydrophobic
grapiprant S274 7.43x42 TM7 Van der Waals
grapiprant V275 7.44x43 TM7 hydrophobic
grapiprant P277 7.46x46 TM7 hydrophobic

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ICL1 R K E Q K E ICL1ECL1 G Q W P G ECL1ICL2 A Y F Y S H Y V ICL2ECL2 L G S S R L Q Y P D T W C F I D W T T N ECL2ICL3 S L G T E Q H H A A A A A S V A S R G H P A A S P A L P R L S D F R R R R S F ICL3ECL3 Q P S L E R E V S K ECL3N-term M S T P G V N S S A S L S P D R L N-termC-term L F C R I G G S R R E R S G Q H C S D S Q R T S S A M S G H S R S F I S R E L K E I S S T S Q T L L P D L S L P D L S E N G L G G R N L L P G V P G M G L A Q E D T T S L R T L R I S E T S D S S Q G Q D S E S V L L V D E A G G S G R A G P A P K G S S L Q V T F P S E T L N L S E K C I C-term N S P V T I P A V M F I F G V V G N L V A I V V L C K S T T F Y T L V C G L A V T D L L G T L L V S P V T I A T Y M K G Q P L C E Y S T F I L L F F S L S G L S I I C A M S V E R Y L A I N H D K R L A G L T L F A V Y A S N V L F C A L P N M G V T A H A A Y S Y M Y A G F S S F L I L A T V L C N V L V C G A L L R M H R Q F M R R T R R I A G A E I Q M V I L L I A T S L V V L I C S I P L V V R V F V N Q L Y N P D L Q A I R I A S V N P I L D P W I Y I L L R K T A I E V L S K K I K C
Helix box plot — Download: PNG | SVG L N G V V G F I F M V A P I T V P S N 1 C G L A V T D L L G T L L V S P V T I A 2 A C I I S L G S L S F F L L I F T S Y E 3 A G L T L F A V Y A S N V L F C A L P N 4 N C L V T A L I L F S S F G A Y M Y S Y 5 I A T S L V V L I C S I P L V V R V F V 6 W P D L I P N V S A I R I A Q L D P N 7

GPCRdb(A)
GPCRdb(A)
EP4 receptor
TM1
1x38 1.38x38 I23
1x39 1.39x39 P24
1x42 1.42x42 M27
TM2
2x53 2.53x53 G68
2x57 2.57x57 V72
2x58 2.58x58 S73
2x61 2.61x61 T76
2x65 2.65x65 Y80
TM3
3x32 3.32x32 L99
TM7
7x35 7.36x35 L312
7x38 7.39x38 I315
7x39 7.40x39 R316
7x41 7.42x41 A318
7x42 7.43x42 S319
7x43 7.44x43 V320
7x46 7.46x46 P322