| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| TG6-129 | S28 | 1.39x39 | TM1 | polar (hydrogen bond) |
| TG6-129 | S28 | 1.39x39 | TM1 | polar (hydrogen bond) |
| TG6-129 | M31 | 1.42x42 | TM1 | Van der Waals |
| TG6-129 | M31 | 1.42x42 | TM1 | hydrophobic |
| TG6-129 | D78 | 2.50x50 | TM2 | Van der Waals |
| TG6-129 | G81 | 2.53x53 | TM2 | Van der Waals |
| TG6-129 | T82 | 2.54x54 | TM2 | Van der Waals |
| TG6-129 | I85 | 2.57x57 | TM2 | Van der Waals |
| TG6-129 | I85 | 2.57x57 | TM2 | hydrophobic |
| TG6-129 | S86 | 2.58x58 | TM2 | polar (hydrogen bond) |
| TG6-129 | V89 | 2.61x61 | TM2 | hydrophobic |
| TG6-129 | V89 | 2.61x61 | TM2 | Van der Waals |
| TG6-129 | Y93 | ECL1 | polar (hydrogen bond) | |
| TG6-129 | Y93 | ECL1 | polar (hydrogen bond) | |
| TG6-129 | F119 | 3.35x35 | TM3 | polar (hydrogen bond with backbone) |
| TG6-129 | F119 | 3.35x35 | TM3 | Van der Waals |
| TG6-129 | T123 | 3.39x39 | TM3 | Van der Waals |
| TG6-129 | T185 | ECL2 | Van der Waals | |
| TG6-129 | W186 | ECL2 | aromatic (face-to-face) | |
| TG6-129 | W186 | ECL2 | polar (hydrogen bond) | |
| TG6-129 | W186 | ECL2 | Van der Waals | |
| TG6-129 | R382 | 7.40x39 | TM7 | Van der Waals |
| TG6-129 | L384 | 7.42x41 | TM7 | Van der Waals |
| TG6-129 | S385 | 7.43x42 | TM7 | Van der Waals |
| TG6-129 | S388 | 7.46x46 | TM7 | polar (hydrogen bond) |
| TG6-129 | S388 | 7.46x46 | TM7 | Van der Waals |
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|
GPCRdb(A)
|
GPCRdb(A)
|
EP2 receptor
|
|---|---|---|
| TM1 | ||
| 1x39 | 1.39x39 | S28 |
| 1x42 | 1.42x42 | M31 |
| TM2 | ||
| 2x50 | 2.50x50 | D78 |
| 2x53 | 2.53x53 | G81 |
| 2x54 | 2.54x54 | T82 |
| 2x57 | 2.57x57 | I85 |
| 2x58 | 2.58x58 | S86 |
| 2x61 | 2.61x61 | V89 |
| TM3 | ||
| 3x35 | 3.35x35 | F119 |
| 3x39 | 3.39x39 | T123 |
| TM7 | ||
| 7x39 | 7.40x39 | R302 |
| 7x41 | 7.42x41 | L304 |
| 7x42 | 7.43x42 | S305 |
| 7x46 | 7.46x46 | S308 |