PDB
9K1D
Resolution
3.3 Å
Released
Dec. 11, 2024
Receptor
FFA2
Class
A
Species
Homo sapiens
Ligands
Function
Cholesterol (R:403)
PAM
butyric acid
Agonist
Cholesterol (R:402)
PAM
Reference
10.1016/J.CELREP.2024.115024
Cholesterol (R:403) butyric acid Cholesterol (R:402)

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Cholesterol (R:403) P43 2.38x38 TM2 hydrophobic
Cholesterol (R:403) L47 2.42x42 TM2 hydrophobic
butyric acid Y90 3.33x33 TM3 hydrophobic
Cholesterol (R:402) W98 3.41x41 TM3 hydrophobic
Cholesterol (R:403) G102 3.45x45 TM3 Van der Waals
Cholesterol (R:402) G102 3.45x45 TM3 Van der Waals
Cholesterol (R:402) I105 3.48x48 TM3 hydrophobic
Cholesterol (R:403) I105 3.48x48 TM3 hydrophobic
Cholesterol (R:403) E106 3.49x49 TM3 Van der Waals
Cholesterol (R:403) L109 3.52x52 TM3 hydrophobic
Cholesterol (R:403) F113 3.56x56 TM3 hydrophobic
Cholesterol (R:403) Q116 34.52x52 ICL2 hydrophobic
Cholesterol (R:403) Y117 34.53x53 ICL2 hydrophobic
Cholesterol (R:403) S120 34.56x56 ICL2 Van der Waals
Cholesterol (R:403) R121 34.57x57 ICL2 Van der Waals
Cholesterol (R:402) Y125 4.41x41 TM4 hydrophobic
Cholesterol (R:403) Y125 4.41x41 TM4 hydrophobic
Cholesterol (R:402) A129 4.45x45 TM4 hydrophobic
Cholesterol (R:403) A129 4.45x45 TM4 hydrophobic
Cholesterol (R:402) V132 4.48x48 TM4 Van der Waals
butyric acid C141 4.57x57 TM4 Van der Waals
butyric acid I143 4.59x59 TM4 Van der Waals
butyric acid V144 4.60x60 TM4 hydrophobic
butyric acid Y165 45.51x51 ECL2 Van der Waals
butyric acid R180 5.39x40 TM5 polar (charge-charge)
butyric acid L183 5.42x43 TM5 hydrophobic
butyric acid Y238 6.51x51 TM6 polar (hydrogen bond)
butyric acid H242 6.55x55 TM6 Van der Waals
butyric acid R255 7.35x34 TM7 polar (charge-charge)
butyric acid R255 7.35x34 TM7 polar (hydrogen bond)

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 P Q P ICL1ECL1 N F R W Y L ECL1ICL2 P V Q Y K L S R ICL2ECL2 T E Q V R S G N E I T C Y E N F T D N ECL2ICL3 P L V ICL3ECL3 K S P W ECL3N-term M L N-termC-term R N Q G S S L L G R R G K D T A E G T N E D R G V G Q G E G M P S S D F T T E C-term P D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R I R Q A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S P K V V C A L T S F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F R P L Y G V I A A L V A W V M S F G H C T I V I I V Q Y L N T Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L S Q G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G Y H Q R W R S I A V V F S S L N A S L D P L L F Y F S S S V F G R L V R R A G L Q V
Helix box plot — Download: PNG | SVG L N A P L G T L F I I I Y A M L I L S S 1 L S L T L A D L L L L L L L P F K I I E 2 G A L L W T S C Y I S S Y F G F S T L A 3 G V I A A L V A W V M S F G H C T I V I 4 Y C F I T V A M P I F F L V L C L E L R V 5 A V V T L L N F V L C F G P Y N V S H L V 6 L P D L S A N L S S F V V A I S R W 7

GPCRdb(A)
GPCRdb(A)
FFA2 receptor
TM2
2x38 2.38x38 P43
2x42 2.42x42 L47
TM3
3x33 3.33x33 Y90
3x41 3.41x41 W98
3x45 3.45x45 G102
3x48 3.48x48 I105
3x49 3.49x49 E106
3x52 3.52x52 L109
3x56 3.56x56 F113
ICL2
34x52 34.52x52 Q116
34x53 34.53x53 Y117
34x56 34.56x56 S120
34x57 34.57x57 R121
TM4
4x41 4.41x41 Y125
4x45 4.45x45 A129
4x48 4.48x48 V132
4x57 4.57x57 C141
4x59 4.59x59 I143
4x60 4.60x60 V144
ECL2
45x51 45.51x51 Y165
TM5
5x40 5.39x40 R180
5x43 5.42x43 L183
TM6
6x51 6.51x51 Y238
6x55 6.55x55 H242
TM7
7x34 7.35x34 R255