PDB
9K1D
Resolution
3.3 Å
Released
Dec. 11, 2024
Receptor
FFA2
Class
A
Species
Homo sapiens
Ligands
butyric acid
Cholesterol
Function
Agonist
PAM
Reference
10.1016/J.CELREP.2024.115024
butyric acid Cholesterol

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Ligand Amino Acid Generic Number Segment Interaction Type
butyric acid Y90 3.33x33 TM3 hydrophobic
Cholesterol W98 3.41x41 TM3 hydrophobic
Cholesterol Y125 4.41x41 TM4 hydrophobic
Cholesterol A129 4.45x45 TM4 hydrophobic
butyric acid I143 4.59x59 TM4 hydrophobic
butyric acid Y165 45.51x51 ECL2 hydrophobic
butyric acid L183 5.42x43 TM5 hydrophobic
butyric acid Y238 6.51x51 TM6 polar (hydrogen bond)
butyric acid R255 7.35x34 TM7 polar (charge-assisted hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 P Q P ICL1ECL1 N F R W Y L ECL1ICL2 P V Q Y K L S R ICL2ECL2 T E Q V R S G N E I T C Y E N F T D N ECL2ICL3 P L V ICL3ECL3 K S P W ECL3N-term M L N-termC-term R N Q G S S L L G R R G K D T A E G T N E D R G V G Q G E G M P S S D F T T E C-term P D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R I R Q A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S P K V V C A L T S F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F R P L Y G V I A A L V A W V M S F G H C T I V I I V Q Y L N T Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L S Q G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G Y H Q R W R S I A V V F S S L N A S L D P L L F Y F S S S V F G R L V R R A G L Q V
Helix box plot — Download: PNG | SVG L N A P L G T L F I I I Y A M L I L S S 1 L S L T L A D L L L L L L L P F K I I E 2 G A L L W T S C Y I S S Y F G F S T L A 3 G V I A A L V A W V M S F G H C T I V I 4 Y C F I T V A M P I F F L V L C L E L R V 5 A V V T L L N F V L C F G P Y N V S H L V 6 L P D L S A N L S S F V V A I S R W 7

GPCRdb(A)
GPCRdb(A)
FFA2 receptor
TM3
3x33 3.33x33 Y90
3x41 3.41x41 W98
TM4
4x41 4.41x41 Y125
4x45 4.45x45 A129
4x59 4.59x59 I143
ECL2
45x51 45.51x51 Y165
TM5
5x43 5.42x43 L183
TM6
6x51 6.51x51 Y238
TM7
7x34 7.35x34 R255