PDB
9KO2
Resolution
3.0 Å
Released
Nov. 26, 2025
Receptor
CCR7
Class
A
Species
Homo sapiens
Ligand
Function
CCL19
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
CCL19 F44 N-term hydrophobic
CCL19 E45 N-term polar (hydrogen bond with backbone)
CCL19 S46 N-term polar (hydrogen bond)
CCL19 S46 N-term polar (hydrogen bond)
CCL19 L47 N-term hydrophobic
CCL19 C48 N-term polar (hydrogen bond with backbone)
CCL19 S49 N-term Van der Waals
CCL19 K50 N-term hydrophobic
CCL19 K50 N-term polar (hydrogen bond with backbone)
CCL19 V53 N-term hydrophobic
CCL19 R54 N-term polar (charge-charge)
CCL19 R54 N-term polar (hydrogen bond)
CCL19 K57 1.31x31 TM1 polar (hydrogen bond)
CCL19 W114 2.60x60 TM2 aromatic (pi-cation)
CCL19 F133 3.29x29 TM3 aromatic (pi-cation)
CCL19 Y136 3.32x32 TM3 polar (hydrogen bond)
CCL19 R201 ECL2 Van der Waals
CCL19 S202 ECL2 Van der Waals
CCL19 S204 ECL2 polar (hydrogen bond)
CCL19 R209 ECL2 polar (charge-charge)
CCL19 C210 45.50x50 ECL2 Van der Waals
CCL19 S211 45.51x51 ECL2 Van der Waals
CCL19 N290 6.62x62 TM6 Van der Waals
CCL19 N305 7.32x31 TM7 Van der Waals
CCL19 Y308 7.35x34 TM7 Van der Waals
CCL19 D309 7.36x35 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K R L K ICL1ECL1 S W V F ECL1ICL2 A V S A H R H R A R ICL2ECL2 D L Q R S S S E Q A M R C S L I T E H V ECL2ICL3 R N ICL3ECL3 T S S ECL3N-term M D L G K P M K S V L V V A L L V I F Q V C L C Q D E V T D D Y I G D N T T V D Y T L F E S L C S K K D V R N-termC-term D L G C L S Q E Q L R Q W S S C R H I R R S S M S V E A E T T T T F S P C-term N F K A W F L P I M Y S I I C F V G L L G N G L V V L T Y I Y F T M T D T Y L L N L A V A D I L F L L T L P F W A Y S A A K G V H F C K L I F A I Y K M S F F S G M L L L L C I S I D R Y V A I V Q V L L I S K L S C V G I W I L A T V L S I P E L L Y S E A F I T I Q V A Q M V I G F L V P L L A M S F C Y L V I I R T L L Q A F E R N K A I K V I I A V V V V F I V F Q L P Y N G V V L A Q T V A N F N I T C E L S K Q L N I A Y D V T Y S L A C V R C C V N P F L Y A F I G V K L F K F R N D L F K
Helix box plot — Download: PNG | SVG G N G L L G V F C I I S Y M I P L F W A 1 L N L A V A D I L F L L T L P F W A Y S 2 C L L L L M G S F F S M K Y I A F I L K 3 S K L S C V G I W I L A T V L S I P E 4 Y C F S M A L L P V L F G I V M Q A V Q I 5 I A V V V V F I V F Q L P Y N G V V L A 6 F P N V C C R V C A L S Y T V D Y A I 7

GPCRdb(A)
GPCRdb(A)
CCR7
TM1
1x31 1.31x31 K57
TM2
2x60 2.60x60 W114
TM3
3x29 3.29x29 F133
3x32 3.32x32 Y136
ECL2
45x50 45.50x50 C210
45x51 45.51x51 S211
TM6
6x62 6.62x62 N290
TM7
7x31 7.32x31 N305
7x34 7.35x34 Y308
7x35 7.36x35 D309