PDB
9KT8
Resolution
2.7 Å
Released
Dec. 10, 2025
Receptor
HCA2
Class
A
Species
Homo sapiens
Ligand
Acifran
Function
Agonist
Reference
10.1021/ACS.JMEDCHEM.4C02567

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Ligand Amino Acid Generic Number Segment Interaction Type
Acifran L83 2.60x60 TM2 hydrophobic
Acifran Y87 2.64x64 TM2 hydrophobic
Acifran W91 ECL1 hydrophobic
Acifran M103 3.28x28 TM3 hydrophobic
Acifran L104 3.29x29 TM3 hydrophobic
Acifran R111 3.36x36 TM3 polar (charge-assisted hydrogen bond)
Acifran C177 45.50x50 ECL2 Van der Waals
Acifran S178 45.51x51 ECL2 Van der Waals
Acifran S179 45.52x52 ECL2 polar (hydrogen bond with backbone)
Acifran S179 45.52x52 ECL2 Van der Waals
Acifran F180 ECL2 hydrophobic
Acifran F180 ECL2 Van der Waals
Acifran F277 7.36x35 TM7 Van der Waals
Acifran L280 7.39x38 TM7 Van der Waals
Acifran Y284 7.43x42 TM7 polar (hydrogen bond)
Acifran Y284 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 L K S W ICL1ECL1 W D W K F ECL1ICL2 P H H A L N K I ICL2ECL2 M P I Q N G G A N L C S S F S I C H T F ECL2ICL3 M D R H A ICL3ECL3 G T Q N C E V ECL3N-term M N R H H L Q D H F L E I D K K N C C V F R D D N-termC-term Q R K M T G E P D N N R S T S V E L T G D P N K T R G A P E A L M A N S G E P W S P S Y L G P T S P C-term F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H S N R T A A I I S C L L W G I T I G L T V H L L K K K Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F S T C L F P N F L I N R
Helix box plot — Download: PNG | SVG G N G L L G F I F E L G L V P P L V K V 1 F N L A V A D F L L I I C L P F L M D N 2 V T L F I I S G Q R N M A L M F L M L R 3 A A I I S C L L W G I T I G L T V H L L 4 S C F L I I G L P L F F E L L F M A E H W 5 M V V A I V F V I C F L P S V V V R I R 6 V P D L M S N M Y T F S L T I F F A L 7

GPCRdb(A)
GPCRdb(A)
HCA2 receptor
TM2
2x60 2.60x60 L83
2x64 2.64x64 Y87
TM3
3x28 3.28x28 M103
3x29 3.29x29 L104
3x36 3.36x36 R111
ECL2
45x50 45.50x50 C177
45x51 45.51x51 S178
45x52 45.52x52 S179
TM7
7x35 7.36x35 F277
7x38 7.39x38 L280
7x42 7.43x42 Y284