PDB
9KV8
Resolution
3.2 Å
Released
Nov. 26, 2025
Receptor
C3a
Class
A
Species
Mus musculus
Ligand
Function
TLQP-21 (Human)
Agonist
Reference
10.1101/2025.05.26.656101

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Ligand Amino Acid Generic Number Segment Interaction Type
TLQP-21 (Human) F77 2.59x59 TM2 Van der Waals
TLQP-21 (Human) S78 2.60x60 TM2 Van der Waals
TLQP-21 (Human) H81 2.63x63 TM2 polar (hydrogen bond)
TLQP-21 (Human) H81 2.63x63 TM2 hydrophobic
TLQP-21 (Human) W88 23.50x50 ECL1 hydrophobic
TLQP-21 (Human) I98 3.28x28 TM3 Van der Waals
TLQP-21 (Human) P99 3.29x29 TM3 Van der Waals
TLQP-21 (Human) I102 3.32x32 TM3 Van der Waals
TLQP-21 (Human) I103 3.33x33 TM3 Van der Waals
TLQP-21 (Human) M106 3.36x36 TM3 Van der Waals
TLQP-21 (Human) I165 ECL2 Van der Waals
TLQP-21 (Human) I171 ECL2 hydrophobic
TLQP-21 (Human) C172 45.50x50 ECL2 Van der Waals
TLQP-21 (Human) Y174 45.52x52 ECL2 Van der Waals
TLQP-21 (Human) R333 5.42x43 TM5 polar (charge-charge)
TLQP-21 (Human) R333 5.42x43 TM5 polar (hydrogen bond)
TLQP-21 (Human) Y386 6.51x51 TM6 polar (hydrogen bond)
TLQP-21 (Human) V389 6.54x54 TM6 Van der Waals
TLQP-21 (Human) L393 6.58x58 TM6 Van der Waals
TLQP-21 (Human) M407 7.32x31 TM7 hydrophobic
TLQP-21 (Human) D410 7.35x34 TM7 polar (hydrogen bond)
TLQP-21 (Human) D410 7.35x34 TM7 polar (charge-charge)
TLQP-21 (Human) H411 7.36x35 TM7 Van der Waals
TLQP-21 (Human) I414 7.39x38 TM7 Van der Waals

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ICL1 M K T ICL1ECL1 G H W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 D L F I M D N R S I C R Y N F D S S R S Y D Y W D Y V Y K L S L P E S N S T D N S T A Q L T G H M N D R S A P S S V Q A R D Y F W T V T T A L Q S Q P F L T S P E D S F S L D S A N Q Q P H Y G G K P P N V L T A A V P S G F P V E D R K S N T L N A D A F L S A H T E L F P T A S S G H L Y P Y D F Q G D Y V D Q F T Y D N H ECL2ICL3 T N F T K S R ICL3ECL3 D P E ECL3N-term M E S F D A D T N S T D L H S R P L F N-termC-term S I K G I L E A A F S E E L T H S T N C T Q D K A S S K R N N M S T D V C-term Q P Q D I A S M V I L G L T C L L G L L G N G L V L W V A G V K T V N T V W F L H L T L A D F L C C L S L P F S L A H L I L Q G L F L C K L I P S I I I L N M F A S V F L L T A I S L D R C L I V H K N V R T A F A I C G C V W V V A F V M C V P V F V Y R V P T P L M A I T I T R L V V G F L V P F F I M V I C Y S L I V F R M R K N K T F R V A V A V V T V F F I C W T P Y H L V G V L L L I T S S L G E A V M S W D H M S I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
Helix box plot — Download: PNG | SVG G N G L L G L L C T L G L I V M S A I D 1 L H L T L A D F L C C L S L P F S L A H 2 A T L L F V S A F M N L I I I S P I L K 3 A F A I C G C V W V V A F V M C V P V 4 Y C I V M I F F P V L F G V V L R T I T I 5 V A V V T V F F I C W T P Y H L V G V L 6 F P N F C S N A S A L A I S M H D W S 7

GPCRdb(A)
GPCRdb(A)
C3a receptor
TM2
2x59 2.59x59 F77
2x60 2.60x60 S78
2x63 2.63x63 H81
ECL1
23x50 23.50x50 W88
TM3
3x28 3.28x28 I98
3x29 3.29x29 P99
3x32 3.32x32 I102
3x33 3.33x33 I103
3x36 3.36x36 M106
ECL2
45x50 45.50x50 C172
45x52 45.52x52 Y174
TM5
5x43 5.42x43 R333
TM6
6x51 6.51x51 Y386
6x54 6.54x54 V389
6x58 6.58x58 L393
TM7
7x31 7.32x31 M407
7x34 7.35x34 D410
7x35 7.36x35 H411
7x38 7.39x38 I414