PDB
9KZ2
Resolution
3.4 Å
Released
Nov. 26, 2025
Receptor
C3a
Class
A
Species
Homo sapiens
Ligand
EP67
Function
Agonist
Reference
10.1073/PNAS.2614459123

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Ligand Amino Acid Generic Number Segment Interaction Type
EP67 P99 3.29x29 TM3 hydrophobic
EP67 I102 3.32x32 TM3 hydrophobic
EP67 F164 ECL2 aromatic (face-to-edge)
EP67 Y174 45.52x52 ECL2 polar (hydrogen bond with backbone)
EP67 Y174 45.52x52 ECL2 Van der Waals
EP67 L333 5.35x36 TM5 Van der Waals
EP67 R340 5.42x43 TM5 polar (charge-assisted hydrogen bond)
EP67 Y393 6.51x51 TM6 polar (hydrogen bond with backbone)
EP67 Y393 6.51x51 TM6 Van der Waals
EP67 F396 6.54x54 TM6 Van der Waals
EP67 G397 6.55x55 TM6 polar (hydrogen bond with backbone)
EP67 G397 6.55x55 TM6 Van der Waals
EP67 D417 7.35x34 TM7 polar (charge-assisted hydrogen bond)
EP67 H418 7.36x35 TM7 Van der Waals
EP67 I421 7.39x38 TM7 Van der Waals
EP67 I421 7.39x38 TM7 hydrophobic

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ICL1 M Q R ICL1ECL1 G Q W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 E I F T T D N H N R C G Y K F G L S S S L D Y P D F Y G D P L E N R S L E N I V Q P P G E M N D R L D P S S F Q T N D H P W T V P T V F Q P Q T F Q R P S A D S L P R G S A R L T S Q N L Y S N V F K P A D V V S P K I P S G F P I E D H E T S P L D N S D A F L S T H L K L F P S A S S N S F Y E S E L P Q G F Q D Y Y N L G Q F T D D D Q ECL2ICL3 G R F A K S Q ICL3ECL3 D P E ECL3N-term M A S F S A E T N S T D L L S Q P W N N-termC-term S I Q G I L E A A F S E E L T R S T H C P S N N V I S E R N S T T V C-term E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K N V G M A C S I C G C I W V V A F V M C I P V F V Y R V P T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
Helix box plot — Download: PNG | SVG G N G P L G L L F T L S L I V M S L I V 1 L H L T L A D L L C C L S L P F S L A H 2 A T L L F V S A F M N L V I I S P I L K 3 A C S I C G C I W V V A F V M C I P V 4 Y C A I M I V S P L L F G V V L R T I T I 5 V V V V A V F L V C W T P Y H I F G V L 6 F P N F C S N A S A L A I C V H D W S 7

GPCRdb(A)
GPCRdb(A)
C3a receptor
TM3
3x29 3.29x29 P99
3x32 3.32x32 I102
ECL2
45x52 45.52x52 Y174
TM5
5x36 5.35x36 L333
5x43 5.42x43 R340
TM6
6x51 6.51x51 Y393
6x54 6.54x54 F396
6x55 6.55x55 G397
TM7
7x34 7.35x34 D417
7x35 7.36x35 H418
7x38 7.39x38 I421