PDB
9KZ8
Resolution
3.3 Å
Released
Nov. 26, 2025
Receptor
C3a
Class
A
Species
Mus musculus
Ligand
Function
EP67
Agonist
Reference
10.1073/PNAS.2614459123

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Ligand Amino Acid Generic Number Segment Interaction Type
EP67 Q20 1.29x29 TM1 hydrophobic
EP67 D23 1.32x32 TM1 Van der Waals
EP67 F77 2.59x59 TM2 hydrophobic
EP67 S78 2.60x60 TM2 Van der Waals
EP67 H81 2.63x63 TM2 Van der Waals
EP67 L82 2.64x64 TM2 Van der Waals
EP67 Q85 ECL1 Van der Waals
EP67 G86 ECL1 Van der Waals
EP67 I98 3.28x28 TM3 hydrophobic
EP67 P99 3.29x29 TM3 hydrophobic
EP67 I102 3.32x32 TM3 hydrophobic
EP67 I103 3.33x33 TM3 Van der Waals
EP67 M106 3.36x36 TM3 hydrophobic
EP67 I171 ECL2 Van der Waals
EP67 C172 45.50x50 ECL2 Van der Waals
EP67 Y174 45.52x52 ECL2 Van der Waals
EP67 R333 5.42x43 TM5 polar (charge-charge)
EP67 Y386 6.51x51 TM6 Van der Waals
EP67 V389 6.54x54 TM6 Van der Waals
EP67 G390 6.55x55 TM6 Van der Waals
EP67 L393 6.58x58 TM6 Van der Waals
EP67 M407 7.32x31 TM7 Van der Waals
EP67 S408 7.33x32 TM7 Van der Waals
EP67 D410 7.35x34 TM7 polar (hydrogen bond)
EP67 D410 7.35x34 TM7 polar (charge-charge)
EP67 H411 7.36x35 TM7 Van der Waals
EP67 I414 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 M K T ICL1ECL1 G H W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 D L F I M D N R S I C R Y N F D S S R S Y D Y W D Y V Y K L S L P E S N S T D N S T A Q L T G H M N D R S A P S S V Q A R D Y F W T V T T A L Q S Q P F L T S P E D S F S L D S A N Q Q P H Y G G K P P N V L T A A V P S G F P V E D R K S N T L N A D A F L S A H T E L F P T A S S G H L Y P Y D F Q G D Y V D Q F T Y D N H ECL2ICL3 T N F T K S R ICL3ECL3 D P E ECL3N-term M E S F D A D T N S T D L H S R P L F N-termC-term S I K G I L E A A F S E E L T H S T N C T Q D K A S S K R N N M S T D V C-term Q P Q D I A S M V I L G L T C L L G L L G N G L V L W V A G V K T V N T V W F L H L T L A D F L C C L S L P F S L A H L I L Q G L F L C K L I P S I I I L N M F A S V F L L T A I S L D R C L I V H K N V R T A F A I C G C V W V V A F V M C V P V F V Y R V P T P L M A I T I T R L V V G F L V P F F I M V I C Y S L I V F R M R K N K T F R V A V A V V T V F F I C W T P Y H L V G V L L L I T S S L G E A V M S W D H M S I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
Helix box plot — Download: PNG | SVG G N G L L G L L C T L G L I V M S A I D 1 L H L T L A D F L C C L S L P F S L A H 2 A T L L F V S A F M N L I I I S P I L K 3 A F A I C G C V W V V A F V M C V P V 4 Y C I V M I F F P V L F G V V L R T I T I 5 V A V V T V F F I C W T P Y H L V G V L 6 F P N F C S N A S A L A I S M H D W S 7

GPCRdb(A)
GPCRdb(A)
C3a receptor
TM1
1x29 1.29x29 Q20
1x32 1.32x32 D23
TM2
2x59 2.59x59 F77
2x60 2.60x60 S78
2x63 2.63x63 H81
2x64 2.64x64 L82
TM3
3x28 3.28x28 I98
3x29 3.29x29 P99
3x32 3.32x32 I102
3x33 3.33x33 I103
3x36 3.36x36 M106
ECL2
45x50 45.50x50 C172
45x52 45.52x52 Y174
TM5
5x43 5.42x43 R333
TM6
6x51 6.51x51 Y386
6x54 6.54x54 V389
6x55 6.55x55 G390
6x58 6.58x58 L393
TM7
7x31 7.32x31 M407
7x32 7.33x32 S408
7x34 7.35x34 D410
7x35 7.36x35 H411
7x38 7.39x38 I414