PDB
9L0H
Resolution
3.6 Å
Released
Nov. 26, 2025
Receptor
C3a
Class
A
Species
Mus musculus
Ligand
Function
JR14a
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
JR14a S78 2.60x60 TM2 Van der Waals
JR14a H81 2.63x63 TM2 Van der Waals
JR14a G86 ECL1 Van der Waals
JR14a I102 3.32x32 TM3 hydrophobic
JR14a Y386 6.51x51 TM6 Van der Waals
JR14a D410 7.35x34 TM7 polar (hydrogen bond)
JR14a D410 7.35x34 TM7 polar (charge-charge)
JR14a H411 7.36x35 TM7 hydrophobic
JR14a H411 7.36x35 TM7 aromatic (face-to-face)
JR14a I414 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 M K T ICL1ECL1 G H W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 D L F I M D N R S I C R Y N F D S S R S Y D Y W D Y V Y K L S L P E S N S T D N S T A Q L T G H M N D R S A P S S V Q A R D Y F W T V T T A L Q S Q P F L T S P E D S F S L D S A N Q Q P H Y G G K P P N V L T A A V P S G F P V E D R K S N T L N A D A F L S A H T E L F P T A S S G H L Y P Y D F Q G D Y V D Q F T Y D N H ECL2ICL3 T N F T K S R ICL3ECL3 D P E ECL3N-term M E S F D A D T N S T D L H S R P L F N-termC-term S I K G I L E A A F S E E L T H S T N C T Q D K A S S K R N N M S T D V C-term Q P Q D I A S M V I L G L T C L L G L L G N G L V L W V A G V K T V N T V W F L H L T L A D F L C C L S L P F S L A H L I L Q G L F L C K L I P S I I I L N M F A S V F L L T A I S L D R C L I V H K N V R T A F A I C G C V W V V A F V M C V P V F V Y R V P T P L M A I T I T R L V V G F L V P F F I M V I C Y S L I V F R M R K N K T F R V A V A V V T V F F I C W T P Y H L V G V L L L I T S S L G E A V M S W D H M S I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
Helix box plot — Download: PNG | SVG G N G L L G L L C T L G L I V M S A I D 1 L H L T L A D F L C C L S L P F S L A H 2 A T L L F V S A F M N L I I I S P I L K 3 A F A I C G C V W V V A F V M C V P V 4 Y C I V M I F F P V L F G V V L R T I T I 5 V A V V T V F F I C W T P Y H L V G V L 6 F P N F C S N A S A L A I S M H D W S 7

GPCRdb(A)
GPCRdb(A)
C3a receptor
TM2
2x60 2.60x60 S78
2x63 2.63x63 H81
TM3
3x32 3.32x32 I102
TM6
6x51 6.51x51 Y386
TM7
7x34 7.35x34 D410
7x35 7.36x35 H411
7x38 7.39x38 I414