PDB
9LDX
Resolution
2.8 Å
Released
Jan. 28, 2026
Receptor
OR6C76
Class
O2
Species
Homo sapiens
Ligands
Function
Benzophenone
Agonist
Cholesterol
PAM
Reference
10.1016/J.CELL.2025.12.017
Benzophenone Cholesterol

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Ligand Amino Acid Generic Number Segment Interaction Type
Cholesterol W70 2.52x52 TM2 hydrophobic
Cholesterol T73 2.55x55 TM2 hydrophobic
Cholesterol V74 2.56x56 TM2 hydrophobic
Cholesterol K78 2.60x60 TM2 hydrophobic
Cholesterol G94 3.24x24 TM3 Van der Waals
Cholesterol T97 3.27x27 TM3 hydrophobic
Cholesterol Q98 3.28x28 TM3 Van der Waals
Cholesterol F101 3.31x31 TM3 hydrophobic
Benzophenone F102 3.32x32 TM3 Van der Waals
Benzophenone I103 3.33x33 TM3 hydrophobic
Cholesterol L105 3.35x35 TM3 hydrophobic
Benzophenone G106 3.36x36 TM3 Van der Waals
Benzophenone C107 3.37x37 TM3 Van der Waals
Benzophenone F110 3.40x40 TM3 aromatic (edge-to-face)
Cholesterol W147 4.50x50 TM4 Van der Waals
Benzophenone I153 4.56x56 TM4 hydrophobic
Benzophenone L200 5.42x42 TM5 hydrophobic
Benzophenone A201 5.43x43 TM5 Van der Waals
Benzophenone T204 5.46x46 TM5 Van der Waals
Benzophenone C253 6.51x51 TM6 Van der Waals
Benzophenone Y257 6.55x55 TM6 hydrophobic
Benzophenone Y257 6.55x55 TM6 aromatic (edge-to-face)

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Snake plot — Download: PNG | SVG
ICL1 S H L K ICL1ECL1 D K S I ECL1ICL2 P L H Y T T I M ICL2ECL2 Q L D F C D S N V I D H F T C D S A P L L Q I S C T D ECL2ICL3 I P ICL3ECL3 K T ECL3N-term M K N R T S V T D F I L L G L T D N-termC-term K H C-term N P Q L Q V V I F S F L F L T Y V L S V T G N L T I I S L T L L D T P M Y F F L R N F S L E I S F T S V C N P R F L I S I L T G S Y N A C A A Q L F F F I F L G S T E F F L L A S M S Y D C Y V A I C K S D R I C Y Q L I I S S W L A G F L V I F P P L A M G L T S T L E L M S F I L A L F T L I S T L I L V I L S Y T Y I I R T I L R S A Q Q R K K A F S T C S S H V I V V S I S Y G S C I F M Y V S A K E G V A L T K G V A I L N T S V A P M L N P F I Y T L R N Q Q F K D I S H V K Q A V L R K K K K
Helix box plot — Download: PNG | SVG L N G T V S L V Y T L F L F S F I V V Q 1 R N F S L E I S F T S V C N P R F L I 2 S A L L F F E T S G L F I F F F L Q A A 3 C Y Q L I I S S W L A G F L V I F P P L 4 Y S L I V L I L T S I L T F L A L I F S 5 S S H V I V V S I S Y G S C I F M Y V 6 F P N L M P A V S T N L I A V G K T L 7

GPCRdb(A)
GPCRdb(A)
OR6C76
TM2
2x52 2.52x52 S69
2x55 2.55x55 S72
2x56 2.56x56 V73
2x60 2.60x60 R77
TM3
3x24 3.24x24 A93
3x27 3.27x27 A96
3x28 3.28x28 Q97
3x31 3.31x31 F100
3x32 3.32x32 F101
3x33 3.33x33 I102
3x35 3.35x35 L104
3x36 3.36x36 G105
3x37 3.37x37 S106
3x40 3.40x40 F109
TM4
4x50 4.50x50 W146
4x56 4.56x56 V152
TM5
5x42 5.42x42 L199
5x43 5.43x43 A200
5x46 5.46x46 T203
TM6
6x51 6.51x51 C252
6x55 6.55x55 Y256