PDB
9LE0
Resolution
2.5 Å
Released
Jan. 28, 2026
Receptor
OR6A2
Class
O2
Species
Homo sapiens
Ligand
Function
Octanal
Agonist
Reference
10.1016/J.CELL.2025.12.017

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Ligand Amino Acid Generic Number Segment Interaction Type
Octanal Y71 2.53x53 TM2 Van der Waals
Octanal F102 3.32x32 TM3 Van der Waals
Octanal L103 3.33x33 TM3 hydrophobic
Octanal G106 3.36x36 TM3 Van der Waals
Octanal C107 3.37x37 TM3 Van der Waals
Octanal K157 4.60x60 TM4 covalent bond
Octanal D197 5.39x39 TM5 Van der Waals
Octanal L200 5.42x42 TM5 Van der Waals
Octanal A201 5.43x43 TM5 Van der Waals
Octanal I204 5.46x46 TM5 hydrophobic
Octanal F249 6.47x47 TM6 hydrophobic
Octanal S253 6.51x51 TM6 Van der Waals
Octanal Y257 6.55x55 TM6 hydrophobic
Octanal Y276 7.41x40 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 S T L H ICL1ECL1 K Q D H G Q L I ECL1ICL2 P L H Y P V I V ICL2ECL2 L S Y C G P N I I N H F F C D V S P L L N L S C T D ECL2ICL3 I P ICL3ECL3 R P K A L S A F ECL3N-term M E W R N H S G R V S E F V L L G F P A N-termC-term H L Y Q H Q D P D P K K A S R N V C-term P A P L Q V L L F A L L L L A Y V L V L T E N T L I I M A I R N H K P M Y F F L A N M S F L E I W Y V T V T I P K M L A G F V G S S F E G C M T Q L Y F F L G L G C T E C V L L A V M A Y D R Y M A I C Y S G R L C V Q M A A G S W A G G F G I S M V K V F L I S G M S T A E L T D F I L A I F I L L G P L S V T G A S Y V A I T G A V M H S A A G R Y K A F S T C A S H L T V V I I F Y A A S I F I Y A D T N K L V S V L Y A V I V P L L N P I I Y C L R N Q E L C C V K R A T L
Helix box plot — Download: PNG | SVG T N E T L V L V Y A L L L L A F L L V Q 1 A N M S F L E I W Y V T V T I P K M L A 2 V A L L V C E T C G L G L F F Y L Q T M 3 C V Q M A A G S W A G G F G I S M V K V 4 Y S A G T V S L P G L L I F I A L I F D 5 A S H L T V V I I F Y A A S I F I Y A 6 I P N L L P V I V A Y L V S V L K N T 7

GPCRdb(A)
GPCRdb(A)
OR6A2
TM2
2x53 2.53x53 Y74
TM3
3x32 3.32x32 F109
3x33 3.33x33 L110
3x36 3.36x36 G113
3x37 3.37x37 C114
TM4
4x60 4.60x60 K164
TM5
5x39 5.39x39 D204
5x42 5.42x42 L207
5x43 5.43x43 A208
5x46 5.46x46 I211
TM6
6x47 6.47x47 F256
6x51 6.51x51 S260
6x55 6.55x55 Y264
TM7
7x40 7.41x40 Y283