PDB
9LLJ
Resolution
2.6 Å
Released
March 4, 2026
Receptor
D1
Class
A
Species
Homo sapiens
Ligands
Function
GEM targeting TM3/4/5
Unknown
Agonist-positive allosteric GEM targeting TM5/6/7
Ago-PAM
GEM targeting TM1/2/4
Unknown
dopamine
Agonist
Reference
—
GEM targeting TM3/4/5 Agonist-positive allosteric GEM targeting TM5/6/7 GEM targeting TM1/2/4 dopamine

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Ligand Amino Acid Generic Number Segment Interaction Type
GEM targeting TM1/2/4 R23 1.32x32 TM1 Van der Waals
GEM targeting TM1/2/4 I34 1.43x43 TM1 hydrophobic
GEM targeting TM1/2/4 L35 1.44x44 TM1 Van der Waals
GEM targeting TM1/2/4 L38 1.47x47 TM1 hydrophobic
GEM targeting TM1/2/4 T42 1.51x51 TM1 Van der Waals
GEM targeting TM1/2/4 C45 1.54x54 TM1 Van der Waals
GEM targeting TM1/2/4 A46 1.55x55 TM1 hydrophobic
GEM targeting TM1/2/4 V48 1.57x57 TM1 hydrophobic
GEM targeting TM1/2/4 I49 1.58x58 TM1 hydrophobic
GEM targeting TM1/2/4 R50 1.59x59 TM1 Van der Waals
GEM targeting TM1/2/4 R55 12.51x51 ICL1 hydrophobic
GEM targeting TM1/2/4 R55 12.51x51 ICL1 aromatic (pi-cation)
GEM targeting TM1/2/4 N60 2.40x40 TM2 Van der Waals
GEM targeting TM1/2/4 F61 2.41x41 TM2 aromatic (edge-to-face)
GEM targeting TM1/2/4 F61 2.41x41 TM2 hydrophobic
GEM targeting TM1/2/4 I64 2.44x44 TM2 hydrophobic
GEM targeting TM1/2/4 S65 2.45x45 TM2 Van der Waals
GEM targeting TM1/2/4 V68 2.48x48 TM2 hydrophobic
GEM targeting TM1/2/4 L71 2.51x51 TM2 Van der Waals
GEM targeting TM1/2/4 L72 2.52x52 TM2 hydrophobic
GEM targeting TM1/2/4 A74 2.54x54 TM2 Van der Waals
GEM targeting TM1/2/4 V75 2.55x55 TM2 hydrophobic
GEM targeting TM1/2/4 L76 2.56x551 TM2 hydrophobic
GEM targeting TM1/2/4 P79 2.59x58 TM2 hydrophobic
GEM targeting TM1/2/4 W80 2.60x59 TM2 hydrophobic
GEM targeting TM1/2/4 W80 2.60x59 TM2 polar (hydrogen bond)
GEM targeting TM1/2/4 V83 2.63x62 TM2 hydrophobic
GEM targeting TM1/2/4 I86 2.66x65 TM2 hydrophobic
GEM targeting TM1/2/4 A87 2.67x66 TM2 hydrophobic
GEM targeting TM1/2/4 F89 23.49x49 ECL1 hydrophobic
GEM targeting TM1/2/4 P91 23.51x51 ECL1 hydrophobic
GEM targeting TM1/2/4 F92 23.52x52 ECL1 hydrophobic
GEM targeting TM1/2/4 F102 3.31x31 TM3 hydrophobic
dopamine D103 3.32x32 TM3 polar (charge-charge)
dopamine D103 3.32x32 TM3 polar (hydrogen bond)
dopamine I104 3.33x33 TM3 hydrophobic
dopamine S107 3.36x36 TM3 Van der Waals
dopamine T108 3.37x37 TM3 Van der Waals
GEM targeting TM3/4/5 L112 3.41x41 TM3 hydrophobic
GEM targeting TM3/4/5 C115 3.44x44 TM3 Van der Waals
GEM targeting TM3/4/5 V116 3.45x45 TM3 hydrophobic
GEM targeting TM3/4/5 V119 3.48x48 TM3 hydrophobic
GEM targeting TM3/4/5 Y122 3.51x51 TM3 hydrophobic
GEM targeting TM3/4/5 W123 3.52x52 TM3 hydrophobic
GEM targeting TM3/4/5 R130 34.52x52 ICL2 polar (charge-charge)
GEM targeting TM3/4/5 R133 34.55x55 ICL2 hydrophobic
GEM targeting TM3/4/5 R133 34.55x55 ICL2 polar (hydrogen bond)
GEM targeting TM3/4/5 R133 34.55x55 ICL2 polar (charge-charge)
GEM targeting TM3/4/5 K134 34.56x56 ICL2 hydrophobic
GEM targeting TM3/4/5 K134 34.56x56 ICL2 polar (hydrogen bond with backbone)
GEM targeting TM3/4/5 K134 34.56x56 ICL2 polar (hydrogen bond)
GEM targeting TM3/4/5 K134 34.56x56 ICL2 polar (charge-charge)
GEM targeting TM3/4/5 T136 4.38x38 TM4 polar (hydrogen bond)
GEM targeting TM1/2/4 P137 4.39x39 TM4 hydrophobic
GEM targeting TM3/4/5 K138 4.40x40 TM4 Van der Waals
GEM targeting TM1/2/4 K138 4.40x40 TM4 Van der Waals
GEM targeting TM3/4/5 A139 4.41x41 TM4 hydrophobic
GEM targeting TM1/2/4 F141 4.43x43 TM4 hydrophobic
GEM targeting TM3/4/5 I142 4.44x44 TM4 hydrophobic
GEM targeting TM3/4/5 L143 4.45x45 TM4 hydrophobic
GEM targeting TM1/2/4 I144 4.46x46 TM4 Van der Waals
GEM targeting TM3/4/5 S145 4.47x47 TM4 Van der Waals
GEM targeting TM3/4/5 V146 4.48x48 TM4 hydrophobic
GEM targeting TM1/2/4 W148 4.50x50 TM4 hydrophobic
GEM targeting TM1/2/4 W148 4.50x50 TM4 aromatic (edge-to-face)
GEM targeting TM3/4/5 T149 4.51x51 TM4 hydrophobic
GEM targeting TM3/4/5 L150 4.52x52 TM4 hydrophobic
GEM targeting TM3/4/5 V152 4.54x54 TM4 hydrophobic
GEM targeting TM3/4/5 L153 4.55x55 TM4 hydrophobic
GEM targeting TM3/4/5 I154 4.56x56 TM4 hydrophobic
GEM targeting TM3/4/5 I157 4.59x59 TM4 hydrophobic
GEM targeting TM3/4/5 P158 4.60x60 TM4 hydrophobic
GEM targeting TM3/4/5 Q160 4.62x62 TM4 polar (hydrogen bond)
GEM targeting TM3/4/5 Q160 4.62x62 TM4 hydrophobic
dopamine L190 ECL2 Van der Waals
GEM targeting TM3/4/5 S191 5.35x36 TM5 polar (hydrogen bond)
GEM targeting TM3/4/5 T193 5.37x38 TM5 Van der Waals
GEM targeting TM3/4/5 Y194 5.38x39 TM5 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 I196 5.40x41 TM5 hydrophobic
GEM targeting TM3/4/5 S197 5.41x42 TM5 Van der Waals
dopamine S198 5.42x43 TM5 polar (hydrogen bond)
dopamine S199 5.43x44 TM5 Van der Waals
GEM targeting TM3/4/5 I201 5.45x46 TM5 hydrophobic
GEM targeting TM3/4/5 I201 5.45x46 TM5 polar (hydrogen bond with backbone)
dopamine S202 5.46x461 TM5 polar (hydrogen bond)
Agonist-positive allosteric GEM targeting TM5/6/7 Y204 5.48x48 TM5 Van der Waals
GEM targeting TM3/4/5 I205 5.49x49 TM5 hydrophobic
GEM targeting TM3/4/5 P206 5.50x50 TM5 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 V207 5.51x51 TM5 Van der Waals
GEM targeting TM3/4/5 I209 5.53x53 TM5 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 I211 5.55x55 TM5 Van der Waals
GEM targeting TM3/4/5 V212 5.56x56 TM5 Van der Waals
GEM targeting TM3/4/5 T213 5.57x57 TM5 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 T215 5.59x59 TM5 Van der Waals
GEM targeting TM3/4/5 R216 5.60x60 TM5 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 F264 6.27x27 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 K265 6.28x28 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 E267 6.30x30 TM6 polar (charge-charge)
Agonist-positive allosteric GEM targeting TM5/6/7 T268 6.31x31 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 L271 6.34x34 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 K272 6.35x35 TM6 polar (charge-charge)
Agonist-positive allosteric GEM targeting TM5/6/7 L274 6.37x37 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 S275 6.38x38 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 V276 6.39x39 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 M278 6.41x41 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 G279 6.42x42 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 V280 6.43x43 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 V282 6.45x45 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 C283 6.46x46 TM6 polar (hydrogen bond with backbone)
dopamine W285 6.48x48 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 L286 6.49x49 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 P287 6.50x50 TM6 hydrophobic
dopamine F288 6.51x51 TM6 hydrophobic
dopamine F288 6.51x51 TM6 aromatic (pi-cation)
dopamine F288 6.51x51 TM6 aromatic (edge-to-face)
dopamine F289 6.52x52 TM6 aromatic (edge-to-face)
Agonist-positive allosteric GEM targeting TM5/6/7 I290 6.53x53 TM6 hydrophobic
dopamine N292 6.55x55 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 C293 6.56x56 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 I294 6.57x57 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 F297 6.60x60 TM6 aromatic (edge-to-face)
Agonist-positive allosteric GEM targeting TM5/6/7 F297 6.60x60 TM6 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 C298 6.61x61 TM6 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 G299 ECL3 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 C307 ECL3 polar (hydrogen bond with backbone)
Agonist-positive allosteric GEM targeting TM5/6/7 I308 ECL3 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 T312 7.34x33 TM7 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 F316 7.38x37 TM7 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 F316 7.38x37 TM7 aromatic (edge-to-face)
dopamine V317 7.39x38 TM7 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 F319 7.41x40 TM7 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 F319 7.41x40 TM7 aromatic (edge-to-face)
dopamine W321 7.43x42 TM7 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 L326 7.48x48 TM7 Van der Waals
Agonist-positive allosteric GEM targeting TM5/6/7 I329 7.51x51 TM7 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 I330 7.52x52 TM7 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 F333 7.55x55 TM7 hydrophobic
Agonist-positive allosteric GEM targeting TM5/6/7 R338 8.51x51 H8 Van der Waals

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NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

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Download PDB file

Snake plot — Download: PNG | SVG
ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
Helix box plot — Download: PNG | SVG T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7

GPCRdb(A)
GPCRdb(A)
D1 receptor
TM1
1x32 1.32x32 R23
1x43 1.43x43 I34
1x44 1.44x44 L35
1x47 1.47x47 L38
1x51 1.51x51 T42
1x54 1.54x54 C45
1x55 1.55x55 A46
1x57 1.57x57 V48
1x58 1.58x58 I49
1x59 1.59x59 R50
ICL1
12x51 12.51x51 R55
TM2
2x40 2.40x40 N60
2x41 2.41x41 F61
2x44 2.44x44 I64
2x45 2.45x45 S65
2x48 2.48x48 V68
2x51 2.51x51 L71
2x52 2.52x52 L72
2x54 2.54x54 A74
2x55 2.55x55 V75
2x551 2.56x551 L76
2x58 2.59x58 P79
2x59 2.60x59 W80
2x62 2.63x62 V83
2x65 2.66x65 I86
2x66 2.67x66 A87
ECL1
23x49 23.49x49 F89
23x51 23.51x51 P91
23x52 23.52x52 F92
TM3
3x31 3.31x31 F102
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
3x37 3.37x37 T108
3x41 3.41x41 L112
3x44 3.44x44 C115
3x45 3.45x45 V116
3x48 3.48x48 V119
3x51 3.51x51 Y122
3x52 3.52x52 W123
ICL2
34x52 34.52x52 R130
34x55 34.55x55 R133
34x56 34.56x56 K134
TM4
4x38 4.38x38 T136
4x39 4.39x39 P137
4x40 4.40x40 K138
4x41 4.41x41 A139
4x43 4.43x43 F141
4x44 4.44x44 I142
4x45 4.45x45 L143
4x46 4.46x46 I144
4x47 4.47x47 S145
4x48 4.48x48 V146
4x50 4.50x50 W148
4x51 4.51x51 T149
4x52 4.52x52 L150
4x54 4.54x54 V152
4x55 4.55x55 L153
4x56 4.56x56 I154
4x59 4.59x59 I157
4x60 4.60x60 P158
4x62 4.62x62 Q160
TM5
5x36 5.35x36 S191
5x38 5.37x38 T193
5x39 5.38x39 Y194
5x41 5.40x41 I196
5x42 5.41x42 S197
5x43 5.42x43 S198
5x44 5.43x44 S199
5x46 5.45x46 I201
5x461 5.46x461 S202
5x48 5.48x48 Y204
5x49 5.49x49 I205
5x50 5.50x50 P206
5x51 5.51x51 V207
5x53 5.53x53 I209
5x55 5.55x55 I211
5x56 5.56x56 V212
5x57 5.57x57 T213
5x59 5.59x59 T215
5x60 5.60x60 R216
TM6
6x27 6.27x27 F264
6x28 6.28x28 K265
6x30 6.30x30 E267
6x31 6.31x31 T268
6x34 6.34x34 L271
6x35 6.35x35 K272
6x37 6.37x37 L274
6x38 6.38x38 S275
6x39 6.39x39 V276
6x41 6.41x41 M278
6x42 6.42x42 G279
6x43 6.43x43 V280
6x45 6.45x45 V282
6x46 6.46x46 C283
6x48 6.48x48 W285
6x49 6.49x49 L286
6x50 6.50x50 P287
6x51 6.51x51 F288
6x52 6.52x52 F289
6x53 6.53x53 I290
6x55 6.55x55 N292
6x56 6.56x56 C293
6x57 6.57x57 I294
6x60 6.60x60 F297
6x61 6.61x61 C298
TM7
7x33 7.34x33 T312
7x37 7.38x37 F316
7x38 7.39x38 V317
7x40 7.41x40 F319
7x42 7.43x42 W321
7x48 7.48x48 L326
7x51 7.51x51 I329
7x52 7.52x52 I330
7x55 7.55x55 F333
H8
8x51 8.51x51 R338