PDB
9LR3
Resolution
2.8 Å
Released
Feb. 4, 2026
Receptor
apelin
Class
A
Species
Homo sapiens
Ligand
Function
azelaprag
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
azelaprag Y35 1.39x39 TM1 Van der Waals
azelaprag F78 2.53x53 TM2 Van der Waals
azelaprag W85 2.60x60 TM2 aromatic (edge-to-face)
azelaprag W85 2.60x60 TM2 hydrophobic
azelaprag I109 3.32x32 TM3 hydrophobic
azelaprag F110 3.33x33 TM3 Van der Waals
azelaprag M113 3.36x36 TM3 hydrophobic
azelaprag R168 4.64x65 TM4 Van der Waals
azelaprag Y264 6.51x51 TM6 aromatic (edge-to-face)
azelaprag V267 6.54x54 TM6 hydrophobic
azelaprag Y271 6.58x58 TM6 aromatic (face-to-face)
azelaprag Y271 6.58x58 TM6 hydrophobic
azelaprag M288 7.32x31 TM7 Van der Waals
azelaprag F291 7.35x34 TM7 aromatic (edge-to-face)
azelaprag F291 7.35x34 TM7 aromatic (face-to-face)
azelaprag F291 7.35x34 TM7 hydrophobic
azelaprag P292 7.36x35 TM7 Van der Waals
azelaprag T295 7.39x38 TM7 Van der Waals
azelaprag Y299 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
Helix box plot — Download: PNG | SVG G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7

GPCRdb(A)
GPCRdb(A)
apelin receptor
TM1
1x39 1.39x39 Y35
TM2
2x53 2.53x53 F78
2x60 2.60x60 W85
TM3
3x32 3.32x32 I109
3x33 3.33x33 F110
3x36 3.36x36 M113
TM4
4x65 4.64x65 R168
TM6
6x51 6.51x51 Y264
6x54 6.54x54 V267
6x58 6.58x58 Y271
TM7
7x31 7.32x31 M288
7x34 7.35x34 F291
7x35 7.36x35 P292
7x38 7.39x38 T295
7x42 7.43x42 Y299