PDB
9M0R
Resolution
2.5 Å
Released
July 23, 2025
Receptor
NPFF1
Class
A
Species
Homo sapiens
Ligand
Function
Neuropeptide VF
Agonist
Reference
10.1016/J.CELREP.2025.116160

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Ligand Amino Acid Generic Number Segment Interaction Type
Neuropeptide VF T100 2.61x60 TM2 Van der Waals
Neuropeptide VF D103 2.64x63 TM2 Van der Waals
Neuropeptide VF N104 2.65x64 TM2 Van der Waals
Neuropeptide VF Q123 3.32x32 TM3 Van der Waals
Neuropeptide VF G124 3.33x33 TM3 Van der Waals
Neuropeptide VF V127 3.36x36 TM3 hydrophobic
Neuropeptide VF S202 ECL2 Van der Waals
Neuropeptide VF C203 45.50x50 ECL2 Van der Waals
Neuropeptide VF W204 45.51x51 ECL2 hydrophobic
Neuropeptide VF E205 45.52x52 ECL2 polar (charge-charge)
Neuropeptide VF T217 5.39x40 TM5 polar (hydrogen bond)
Neuropeptide VF L220 5.42x43 TM5 hydrophobic
Neuropeptide VF W287 6.52x52 TM6 hydrophobic
Neuropeptide VF L290 6.55x55 TM6 hydrophobic
Neuropeptide VF D294 6.59x59 TM6 polar (charge-charge)
Neuropeptide VF T307 7.31x30 TM7 hydrophobic
Neuropeptide VF F311 7.35x34 TM7 hydrophobic
Neuropeptide VF H315 7.39x38 TM7 Van der Waals
Neuropeptide VF F319 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R H M H ICL1ECL1 G W P F ECL1ICL2 P F R E K L ICL2ECL2 T V T R E E H H F M V D A R N R S Y P L Y S C W E A W P E K ECL2ICL3 G G E E A ICL3ECL3 Q L S A P Q L ECL3N-term M E G E P S Q P P N S S W P L S Q N G T N T E A T P A T N L T F S S Y Y Q H T S P V N-termC-term P R P S G S H K E A Y S E R P G G L L H R R V F V V V R P S D S G L P S E S G P S S G A P R P G R L P L R N G R V A H H G L P R E G P G C S H L P L T I P A W D I C-term A A M F I V A Y A L I F L L C M V G N T L V C F I V L K N T V T N M F I L N L A V S D L L V G I F C M P T T L V D N L I T D N A T C K M S G L V Q G M S V S A S V F T L V A I A V E R F R C I V H T L R K A L V T I A V I W A L A L L I M C P S A V T L G M R R V Y T T V L F S H I Y L A P L A L I V V M Y A R I A R K L C Q A P G P A P A D P R A S R R R A R V V H M L V M V A L F F T L S W L P L W A L L L L I D Y G H L V T V Y A F P F A H W L A F F N S S A N P I I Y G Y F N E N F Q A R L C F R R G A F R A
Helix box plot — Download: PNG | SVG T N G V M C L L F I L A Y A V I F M A A 1 L N L A V S D L L V G F I C M P T T L V D 2 A V L T F V S A S V S M G Q V L G S M K 3 A L V T I A V I W A L A L L I M C P S 4 Y M V V I L A L P A L Y I H S F L V T T Y 5 V M V A L F F T L S W L P L W A L L L L 6 I P N A S S N F F A L W H A F P F A Y 7

GPCRdb(A)
GPCRdb(A)
NPFF1 receptor
TM2
2x60 2.61x60 T100
2x63 2.64x63 D103
2x64 2.65x64 N104
TM3
3x32 3.32x32 Q123
3x33 3.33x33 G124
3x36 3.36x36 V127
ECL2
45x50 45.50x50 C203
45x51 45.51x51 W204
45x52 45.52x52 E205
TM5
5x40 5.39x40 T217
5x43 5.42x43 L220
TM6
6x52 6.52x52 W287
6x55 6.55x55 L290
6x59 6.59x59 D294
TM7
7x30 7.31x30 T307
7x34 7.35x34 F311
7x38 7.39x38 H315
7x42 7.43x42 F319