PDB
9M1O
Resolution
2.5 Å
Released
July 23, 2025
Receptor
NPFF2
Class
A
Species
Homo sapiens
Ligand
Function
neuropeptide FF (Human)
Agonist
Reference
10.1016/J.CELREP.2025.116160

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Ligand Amino Acid Generic Number Segment Interaction Type
neuropeptide FF (Human) T135 N-term Van der Waals
neuropeptide FF (Human) Y136 N-term Van der Waals
neuropeptide FF (Human) V137 N-term hydrophobic
neuropeptide FF (Human) L141 N-term hydrophobic
neuropeptide FF (Human) C200 2.57x56 TM2 Van der Waals
neuropeptide FF (Human) D207 2.64x63 TM2 Van der Waals
neuropeptide FF (Human) N208 2.65x64 TM2 Van der Waals
neuropeptide FF (Human) I210 2.67x66 TM2 Van der Waals
neuropeptide FF (Human) A211 ECL1 Van der Waals
neuropeptide FF (Human) G212 23.49x49 ECL1 Van der Waals
neuropeptide FF (Human) W213 23.50x50 ECL1 Van der Waals
neuropeptide FF (Human) Q227 3.32x32 TM3 Van der Waals
neuropeptide FF (Human) G228 3.33x33 TM3 Van der Waals
neuropeptide FF (Human) V231 3.36x36 TM3 hydrophobic
neuropeptide FF (Human) M277 4.57x57 TM4 hydrophobic
neuropeptide FF (Human) Y292 ECL2 aromatic (face-to-face)
neuropeptide FF (Human) Y292 ECL2 aromatic (pi-cation)
neuropeptide FF (Human) Y292 ECL2 hydrophobic
neuropeptide FF (Human) W307 ECL2 hydrophobic
neuropeptide FF (Human) C308 45.50x50 ECL2 Van der Waals
neuropeptide FF (Human) R309 45.51x51 ECL2 Van der Waals
neuropeptide FF (Human) R318 5.35x36 TM5 Van der Waals
neuropeptide FF (Human) T322 5.39x40 TM5 Van der Waals
neuropeptide FF (Human) W389 6.48x48 TM6 Van der Waals
neuropeptide FF (Human) L392 6.51x51 TM6 hydrophobic
neuropeptide FF (Human) W393 6.52x52 TM6 hydrophobic
neuropeptide FF (Human) M396 6.55x55 TM6 hydrophobic
neuropeptide FF (Human) D400 6.59x59 TM6 polar (charge-charge)
neuropeptide FF (Human) Q410 7.28x27 TM7 polar (hydrogen bond)
neuropeptide FF (Human) N413 7.31x30 TM7 Van der Waals
neuropeptide FF (Human) I414 7.32x31 TM7 Van der Waals
neuropeptide FF (Human) Y417 7.35x34 TM7 hydrophobic
neuropeptide FF (Human) H421 7.39x38 TM7 polar (hydrogen bond)

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ICL1 K H M H ICL1ECL1 G W P F ECL1ICL2 P F K P K L ICL2ECL2 H V Q E E K Y Y R V R L N S Q N K T S P V Y W C R E D W P N Q ECL2ICL3 G R K N Q E Q W ICL3ECL3 D L S P N E L ECL3N-term M N S F F G T P A A S W C L L E S D V S S A P D K E A G R E R R A L S V Q Q R G G P A W S G S L E W S R Q S A G D R R R L G L S R Q T A K S S W S R S R D R T C C C R R A W W I L V P A A D R A R R E R F I M N E K W D T N S S E N W H P I W N V N D T K H H L Y S D I N I T Y V N Y Y L H Q P Q V N-termC-term Q K R A K P M E A Y A L K A K S H V L I N T S N Q L V Q E S T F Q N P H G E T L L Y R K S A E K P Q Q E L V M E E L K E T T N S S E I C-term A A I F I I S Y F L I F F L C M M G N T V V C F I V M R N T V T N L F I L N L A I S D L L V G I F C M P I T L L D N I I A G N T M C K I S G L V Q G I S V A A S V F T L V A I A V D R F Q C V V Y T I K T A F V I I M I I W V L A I T I M S P S A V M L E M R K I Y T T V L F A N I Y L A P L S L I V I M Y G R I G I S L F R A A V P H T H V V S R K K Q K I I K M L L I V A L L F I L S W L P L W T L M M L S D Y A Q I I N I Y I Y P F A H W L A F G N S S V N P I I Y G F F N E N F Q E Q L C F R R G A F Q L
Helix box plot — Download: PNG | SVG T N G M M C L F F I L F Y S I I F I A A 1 L N L A I S D L L V G F I C M P I T L L D 2 A V L T F V S A A V S I G Q V L G S I K 3 A F V I I M I I W V L A I T I M S P S 4 Y M I V I L S L P A L Y I N A F L V T T Y 5 L I V A L L F I L S W L P L W T L M M L 6 I P N V S S N G F A L W H A F P Y I Y 7

GPCRdb(A)
GPCRdb(A)
NPFF2 receptor
TM2
2x56 2.57x56 C200
2x63 2.64x63 D207
2x64 2.65x64 N208
2x66 2.67x66 I210
ECL1
23x49 23.49x49 G212
23x50 23.50x50 W213
TM3
3x32 3.32x32 Q227
3x33 3.33x33 G228
3x36 3.36x36 V231
TM4
4x57 4.57x57 M277
ECL2
45x50 45.50x50 C308
45x51 45.51x51 R309
TM5
5x36 5.35x36 R318
5x40 5.39x40 T322
TM6
6x48 6.48x48 W389
6x51 6.51x51 L392
6x52 6.52x52 W393
6x55 6.55x55 M396
6x59 6.59x59 D400
TM7
7x27 7.28x27 Q410
7x30 7.31x30 N413
7x31 7.32x31 I414
7x34 7.35x34 Y417
7x38 7.39x38 H421