PDB
9MB9
Resolution
3.0 Å
Released
Oct. 1, 2025
Receptor
mGlu8
Class
C
Species
Homo sapiens
Ligands
Function
(S)-3,4-DCPG
Agonist
VU0422288
Ago-PAM
Reference
—
(S)-3,4-DCPG VU0422288

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Ligand Amino Acid Generic Number Segment Interaction Type
(S)-3,4-DCPG K68 N-term polar (charge-charge)
(S)-3,4-DCPG K71 N-term polar (charge-charge)
(S)-3,4-DCPG K71 N-term polar (hydrogen bond)
(S)-3,4-DCPG R75 N-term polar (charge-charge)
(S)-3,4-DCPG R75 N-term polar (hydrogen bond)
(S)-3,4-DCPG A154 N-term hydrophobic
(S)-3,4-DCPG A155 N-term Van der Waals
(S)-3,4-DCPG S156 N-term polar (hydrogen bond with backbone)
(S)-3,4-DCPG S156 N-term polar (hydrogen bond)
(S)-3,4-DCPG A177 N-term hydrophobic
(S)-3,4-DCPG A177 N-term polar (hydrogen bond with backbone)
(S)-3,4-DCPG S178 N-term Van der Waals
(S)-3,4-DCPG T179 N-term polar (hydrogen bond with backbone)
(S)-3,4-DCPG T179 N-term polar (hydrogen bond)
(S)-3,4-DCPG Y227 N-term Van der Waals
(S)-3,4-DCPG D309 N-term polar (charge-charge)
(S)-3,4-DCPG S310 N-term Van der Waals
(S)-3,4-DCPG K314 N-term polar (hydrogen bond)
(S)-3,4-DCPG K314 N-term polar (charge-charge)
(S)-3,4-DCPG K401 N-term polar (hydrogen bond)
(S)-3,4-DCPG K401 N-term polar (charge-charge)
(S)-3,4-DCPG K401 N-term aromatic (pi-cation)
VU0422288 I792 6.48x48 TM6 Van der Waals
VU0422288 L795 6.51x51 TM6 hydrophobic
VU0422288 L795 6.51x51 TM6 polar (hydrogen bond with backbone)
VU0422288 A796 6.52x52 TM6 Van der Waals
VU0422288 I798 6.54x54 TM6 hydrophobic
VU0422288 P799 6.55x55 TM6 hydrophobic
VU0422288 F802 6.58x58 TM6 hydrophobic
VU0422288 G803 6.59x59 TM6 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

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NGL is a WebGL based 3D viewer powered by MMTF.

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Snake plot — Download: PNG | SVG
ICL1 T N D P I V R A S ICL1ECL1 A P ECL1ICL2 G K K S V T A P K F I ICL2ECL2 P P H I I I D Y G E Q R T L D P E K A R G V L K C D I ECL2ICL3 G V P E T ICL3ECL3 A Q S A E K M Y ECL3N-term M V C E G K R S A S C P C F F L L T A K F Y W I L T M M Q R T H S Q E Y A H S I R V D G D I I L G G L F P V H A K G E R G V P C G E L K K E K G I H R L E A M L Y A I D Q I N K D P D L L S N I T L G V R I L D T C S R D T Y A L E Q S L T F V Q A L I E K D A S D V K C A N G D P P I F T K P D K I S G V I G A A A S S V S I M V A N I L R L F K I P Q I S Y A S T A P E L S D N T R Y D F F S R V V P P D S Y Q A Q A M V D I V T A L G W N Y V S T L A S E G N Y G E S G V E A F T Q I S R E I G G V C I A Q S Q K I P R E P R P G E F E K I I K R L L E T P N A R A V I M F A N E D D I R R I L E A A K K L N Q S G H F L W I G S D S W G S K I A P V Y Q Q E E I A E G A V T I L P K R A S I D G F D R Y F R S R T L A N N R R N V W F A E F W E E N F G C K L G S H G K R N S H I K K C T G L E R I A R D S S Y E Q E G K V Q F V I D A V Y S M A Y A L H N M H K D L C P G Y I G L C P R M S T I D G K E L L G Y I R A V N F N G S A G T P V T F N E N G D A P G R Y D I F Q Y Q I T N K S T E Y K V I G H W T N Q L H L K V E D M Q W A H R E H T H P A S V C S L P C K P G E R K K T V K G V P C C W H C E R C E G Y N Y Q V D E L S C E L C P L D Q R P N M N R T G C Q L I P I I K L E W H S P N-termC-term K A V V T A A T M Q S K L I Q K G N D R P N G E V K S E L C E S L E T N T S S T K T T Y I S Y S N H S I C-term W A V V P V F V A I L G I I A T T F V I V T F V R Y G R E L S Y V L L T G I F L C Y S I T F L M I A D T I I C S F R R V F L G L G M C F S Y A A L L T K T N R I H R I F E Q S P A S Q L V I T F S L I S V Q L L G V F V W F V V D S D L S L I C S L G Y S I L L M V T C T V Y A I K T R F N E A K P I G F T M Y T T C I I W L A F I P I F F G T I Q T T T L T V S M S L S A S V S L G M L Y M P K V Y I I I F H P E Q R K R N V Q K S F
Helix box plot — Download: PNG | SVG T T A I I G L I A V F V P V V A W 1 Y V L L T G I F L C Y S I T F L M I A 2 T L L A A Y S F C M G L G L F V R R F S 3 Q L V I T F S L I S V Q L L G V F V W F 4 A Y V T C T V M L L I S Y G L S C I L S 5 G F T M Y T T C I I W L A F I P I F F G 6 G L S V S A S L S M S V T L T T T Q I 7

GPCRdb(A)
GPCRdb(C)
mGlu8 receptor
TM6
6x46 6.48x48 I792
6x49 6.51x51 L795
6x50 6.52x52 A796
6x52 6.54x54 I798
6x53 6.55x55 P799
6x56 6.58x58 F802
6x57 6.59x59 G803