PDB
9MBC
Resolution
3.0 Å
Released
Oct. 1, 2025
Receptor
mGlu8
Class
C
Species
Homo sapiens
Ligands
Function
(S)-3,4-DCPG
Agonist
AZ12216052
Ago-PAM
Reference
—
(S)-3,4-DCPG AZ12216052

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Ligand Amino Acid Generic Number Segment Interaction Type
(S)-3,4-DCPG K71 N-term polar (charge-charge)
(S)-3,4-DCPG R75 N-term polar (charge-charge)
(S)-3,4-DCPG R75 N-term polar (hydrogen bond)
(S)-3,4-DCPG A154 N-term Van der Waals
(S)-3,4-DCPG A155 N-term Van der Waals
(S)-3,4-DCPG S156 N-term polar (hydrogen bond with backbone)
(S)-3,4-DCPG S156 N-term polar (hydrogen bond)
(S)-3,4-DCPG A177 N-term hydrophobic
(S)-3,4-DCPG S178 N-term Van der Waals
(S)-3,4-DCPG T179 N-term polar (hydrogen bond)
(S)-3,4-DCPG T179 N-term polar (hydrogen bond with backbone)
(S)-3,4-DCPG Y227 N-term Van der Waals
(S)-3,4-DCPG D309 N-term polar (charge-charge)
(S)-3,4-DCPG D309 N-term polar (hydrogen bond)
(S)-3,4-DCPG S310 N-term Van der Waals
(S)-3,4-DCPG K314 N-term polar (charge-charge)
(S)-3,4-DCPG K314 N-term polar (hydrogen bond)
(S)-3,4-DCPG K401 N-term aromatic (pi-cation)
AZ12216052 W583 N-term Van der Waals
AZ12216052 I793 6.49x49 TM6 Van der Waals
AZ12216052 I800 6.56x56 TM6 hydrophobic
AZ12216052 I813 7.27x28 TM7 hydrophobic
AZ12216052 T816 7.30x31 TM7 hydrophobic
AZ12216052 T817 7.31x32 TM7 Van der Waals
AZ12216052 V820 7.34x35 TM7 hydrophobic
AZ12216052 S821 7.35x36 TM7 Van der Waals
AZ12216052 L824 7.38x39 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

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NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T N D P I V R A S ICL1ECL1 A P ECL1ICL2 G K K S V T A P K F I ICL2ECL2 P P H I I I D Y G E Q R T L D P E K A R G V L K C D I ECL2ICL3 G V P E T ICL3ECL3 A Q S A E K M Y ECL3N-term M V C E G K R S A S C P C F F L L T A K F Y W I L T M M Q R T H S Q E Y A H S I R V D G D I I L G G L F P V H A K G E R G V P C G E L K K E K G I H R L E A M L Y A I D Q I N K D P D L L S N I T L G V R I L D T C S R D T Y A L E Q S L T F V Q A L I E K D A S D V K C A N G D P P I F T K P D K I S G V I G A A A S S V S I M V A N I L R L F K I P Q I S Y A S T A P E L S D N T R Y D F F S R V V P P D S Y Q A Q A M V D I V T A L G W N Y V S T L A S E G N Y G E S G V E A F T Q I S R E I G G V C I A Q S Q K I P R E P R P G E F E K I I K R L L E T P N A R A V I M F A N E D D I R R I L E A A K K L N Q S G H F L W I G S D S W G S K I A P V Y Q Q E E I A E G A V T I L P K R A S I D G F D R Y F R S R T L A N N R R N V W F A E F W E E N F G C K L G S H G K R N S H I K K C T G L E R I A R D S S Y E Q E G K V Q F V I D A V Y S M A Y A L H N M H K D L C P G Y I G L C P R M S T I D G K E L L G Y I R A V N F N G S A G T P V T F N E N G D A P G R Y D I F Q Y Q I T N K S T E Y K V I G H W T N Q L H L K V E D M Q W A H R E H T H P A S V C S L P C K P G E R K K T V K G V P C C W H C E R C E G Y N Y Q V D E L S C E L C P L D Q R P N M N R T G C Q L I P I I K L E W H S P N-termC-term K A V V T A A T M Q S K L I Q K G N D R P N G E V K S E L C E S L E T N T S S T K T T Y I S Y S N H S I C-term W A V V P V F V A I L G I I A T T F V I V T F V R Y G R E L S Y V L L T G I F L C Y S I T F L M I A D T I I C S F R R V F L G L G M C F S Y A A L L T K T N R I H R I F E Q S P A S Q L V I T F S L I S V Q L L G V F V W F V V D S D L S L I C S L G Y S I L L M V T C T V Y A I K T R F N E A K P I G F T M Y T T C I I W L A F I P I F F G T I Q T T T L T V S M S L S A S V S L G M L Y M P K V Y I I I F H P E Q R K R N V Q K S F
Helix box plot — Download: PNG | SVG T T A I I G L I A V F V P V V A W 1 Y V L L T G I F L C Y S I T F L M I A 2 T L L A A Y S F C M G L G L F V R R F S 3 Q L V I T F S L I S V Q L L G V F V W F 4 A Y V T C T V M L L I S Y G L S C I L S 5 G F T M Y T T C I I W L A F I P I F F G 6 G L S V S A S L S M S V T L T T T Q I 7

GPCRdb(A)
GPCRdb(C)
mGlu8 receptor
TM6
6x47 6.49x49 I793
6x54 6.56x56 I800
TM7
7x33 7.27x28 I813
7x36 7.30x31 T816
7x37 7.31x32 T817
7x40 7.34x35 V820
7x41 7.35x36 S821
7x44 7.38x39 L824