PDB
9MZE
Resolution
2.2 Å
Released
April 22, 2026
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
Function
Oxyntomodulin
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
Oxyntomodulin S31 N-term Van der Waals
Oxyntomodulin L32 N-term hydrophobic
Oxyntomodulin L32 N-term polar (hydrogen bond with backbone)
Oxyntomodulin T35 N-term hydrophobic
Oxyntomodulin V36 N-term Van der Waals
Oxyntomodulin W39 N-term Van der Waals
Oxyntomodulin E68 N-term hydrophobic
Oxyntomodulin Y69 N-term hydrophobic
Oxyntomodulin Y88 N-term Van der Waals
Oxyntomodulin L89 N-term hydrophobic
Oxyntomodulin P90 N-term Van der Waals
Oxyntomodulin W91 N-term hydrophobic
Oxyntomodulin R121 N-term polar (hydrogen bond)
Oxyntomodulin L123 N-term hydrophobic
Oxyntomodulin S129 N-term Van der Waals
Oxyntomodulin P137 N-term Van der Waals
Oxyntomodulin E138 1.33x33 TM1 polar (hydrogen bond)
Oxyntomodulin E138 1.33x33 TM1 polar (charge-charge)
Oxyntomodulin L141 1.36x36 TM1 hydrophobic
Oxyntomodulin L142 1.37x37 TM1 Van der Waals
Oxyntomodulin L144 1.39x39 TM1 hydrophobic
Oxyntomodulin Y148 1.43x43 TM1 hydrophobic
Oxyntomodulin Y148 1.43x43 TM1 aromatic (edge-to-face)
Oxyntomodulin Y152 1.47x47 TM1 Van der Waals
Oxyntomodulin V194 2.64x64 TM2 Van der Waals
Oxyntomodulin K197 2.67x67 TM2 Van der Waals
Oxyntomodulin L201 2.71x71 TM2 hydrophobic
Oxyntomodulin Y205 ECL1 hydrophobic
Oxyntomodulin Y205 ECL1 polar (hydrogen bond)
Oxyntomodulin Y205 ECL1 polar (hydrogen bond with backbone)
Oxyntomodulin S206 ECL1 Van der Waals
Oxyntomodulin A209 ECL1 Van der Waals
Oxyntomodulin Q210 ECL1 Van der Waals
Oxyntomodulin Q211 ECL1 hydrophobic
Oxyntomodulin W214 ECL1 aromatic (edge-to-face)
Oxyntomodulin F230 3.33x33 TM3 Van der Waals
Oxyntomodulin M233 3.36x36 TM3 Van der Waals
Oxyntomodulin Q234 3.37x37 TM3 polar (hydrogen bond)
Oxyntomodulin V237 3.40x40 TM3 Van der Waals
Oxyntomodulin Y241 3.44x44 TM3 Van der Waals
Oxyntomodulin T298 45.52x52 ECL2 polar (hydrogen bond)
Oxyntomodulin R299 ECL2 hydrophobic
Oxyntomodulin R299 ECL2 polar (charge-charge)
Oxyntomodulin R299 ECL2 polar (hydrogen bond)
Oxyntomodulin N300 ECL2 polar (hydrogen bond with backbone)
Oxyntomodulin W306 5.36x37 TM5 aromatic (edge-to-face)
Oxyntomodulin I309 5.39x39 TM5 Van der Waals
Oxyntomodulin R310 5.40x40 TM5 Van der Waals
Oxyntomodulin I313 5.43x43 TM5 Van der Waals
Oxyntomodulin D372 ECL3 polar (hydrogen bond)
Oxyntomodulin R380 7.35x34 TM7 polar (hydrogen bond)
Oxyntomodulin R380 7.35x34 TM7 polar (charge-charge)
Oxyntomodulin L384 7.39x38 TM7 hydrophobic
Oxyntomodulin E387 7.42x41 TM7 Van der Waals
Oxyntomodulin L388 7.43x42 TM7 hydrophobic

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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x29 1.33x33 E138
1x32 1.36x36 L141
1x33 1.37x37 L142
1x35 1.39x39 L144
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x57 2.64x64 V194
2x60 2.67x67 K197
2x64 2.71x71 L201
TM3
3x29 3.33x33 F230
3x32 3.36x36 M233
3x33 3.37x37 Q234
3x36 3.40x40 V237
3x40 3.44x44 Y241
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
5x43 5.39x39 I309
5x44 5.40x40 R310
5x47 5.43x43 I313
TM7
7x30 7.35x34 R380
7x34 7.39x38 L384
7x37 7.42x41 E387
7x38 7.43x42 L388