PDB
9N0E
Resolution
2.3 Å
Released
April 22, 2026
Receptor
glucagon
Class
B1
Species
Homo sapiens
Ligand
Function
Oxyntomodulin
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Oxyntomodulin A25 hydrophobic
Oxyntomodulin A26 N-term Van der Waals
Oxyntomodulin Q27 N-term Van der Waals
Oxyntomodulin V28 N-term hydrophobic
Oxyntomodulin V28 N-term polar (hydrogen bond with backbone)
Oxyntomodulin M29 N-term hydrophobic
Oxyntomodulin M29 N-term polar (hydrogen bond with backbone)
Oxyntomodulin L32 N-term hydrophobic
Oxyntomodulin F33 N-term hydrophobic
Oxyntomodulin W36 N-term hydrophobic
Oxyntomodulin W36 N-term aromatic (edge-to-face)
Oxyntomodulin K64 N-term hydrophobic
Oxyntomodulin K64 N-term polar (hydrogen bond)
Oxyntomodulin K64 N-term aromatic (pi-cation)
Oxyntomodulin Y65 N-term hydrophobic
Oxyntomodulin Y84 N-term hydrophobic
Oxyntomodulin P86 N-term Van der Waals
Oxyntomodulin W87 N-term hydrophobic
Oxyntomodulin R116 N-term polar (hydrogen bond)
Oxyntomodulin Q122 N-term Van der Waals
Oxyntomodulin M123 N-term hydrophobic
Oxyntomodulin Q131 1.29x29 TM1 polar (hydrogen bond)
Oxyntomodulin Q131 1.29x29 TM1 hydrophobic
Oxyntomodulin A135 1.33x33 TM1 hydrophobic
Oxyntomodulin Y138 1.36x36 TM1 hydrophobic
Oxyntomodulin Y138 1.36x36 TM1 aromatic (edge-to-face)
Oxyntomodulin F141 1.39x39 TM1 hydrophobic
Oxyntomodulin Q142 1.40x40 TM1 Van der Waals
Oxyntomodulin Y145 1.43x43 TM1 hydrophobic
Oxyntomodulin Y149 1.47x47 TM1 polar (hydrogen bond)
Oxyntomodulin V191 2.64x64 TM2 hydrophobic
Oxyntomodulin L198 2.71x71 TM2 Van der Waals
Oxyntomodulin R201 2.74x74 TM2 Van der Waals
Oxyntomodulin Y202 2.75x75 TM2 hydrophobic
Oxyntomodulin Q204 ECL1 Van der Waals
Oxyntomodulin I206 ECL1 hydrophobic
Oxyntomodulin G207 ECL1 Van der Waals
Oxyntomodulin D208 ECL1 Van der Waals
Oxyntomodulin D209 ECL1 Van der Waals
Oxyntomodulin V212 ECL1 hydrophobic
Oxyntomodulin W215 ECL1 aromatic (pi-cation)
Oxyntomodulin Q232 3.37x37 TM3 Van der Waals
Oxyntomodulin I235 3.40x40 TM3 Van der Waals
Oxyntomodulin Y239 3.44x44 TM3 hydrophobic
Oxyntomodulin T296 45.52x52 ECL2 polar (hydrogen bond)
Oxyntomodulin S297 ECL2 Van der Waals
Oxyntomodulin N298 ECL2 polar (hydrogen bond with backbone)
Oxyntomodulin W304 5.36x37 TM5 aromatic (edge-to-face)
Oxyntomodulin R308 5.40x40 TM5 Van der Waals
Oxyntomodulin D370 ECL3 polar (hydrogen bond)
Oxyntomodulin R378 7.35x34 TM7 polar (hydrogen bond)
Oxyntomodulin R378 7.35x34 TM7 polar (charge-charge)
Oxyntomodulin L382 7.39x38 TM7 hydrophobic
Oxyntomodulin D385 7.42x41 TM7 Van der Waals
Oxyntomodulin L386 7.43x42 TM7 hydrophobic

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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
Helix box plot — Download: PNG | SVG L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7

GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM1
1x25 1.29x29 Q131
1x29 1.33x33 A135
1x32 1.36x36 Y138
1x35 1.39x39 F141
1x36 1.40x40 Q142
1x39 1.43x43 Y145
1x43 1.47x47 Y149
TM2
2x57 2.64x64 V191
2x64 2.71x71 L198
2x67 2.74x74 R201
2x68 2.75x75 Y202
TM3
3x33 3.37x37 Q232
3x36 3.40x40 I235
3x40 3.44x44 Y239
ECL2
45x52 45.52x52 T296
TM5
5x41 5.36x37 W304
5x44 5.40x40 R308
TM7
7x30 7.35x34 R378
7x34 7.39x38 L382
7x37 7.42x41 D385
7x38 7.43x42 L386