PDB
9NS9
Resolution
3.3 Å
Released
June 25, 2025
Receptor
FFA2
Class
A
Species
Homo sapiens
Ligands
CHEMBL4176503
CHEMBL5965059
Function
Agonist
Ago-PAM
Reference
—
CHEMBL4176503 CHEMBL5965059

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4176503 F87 3.30x30 TM3 hydrophobic
CHEMBL4176503 Y90 3.33x33 TM3 aromatic (edge-to-face)
CHEMBL5965059 E106 3.49x49 TM3 polar (charge-assisted hydrogen bond)
CHEMBL5965059 L109 3.52x52 TM3 hydrophobic
CHEMBL5965059 L109 3.52x52 TM3 Van der Waals
CHEMBL5965059 Y117 34.53x53 ICL2 Van der Waals
CHEMBL5965059 S120 34.56x56 ICL2 polar (hydrogen bond with backbone)
CHEMBL5965059 S120 34.56x56 ICL2 Van der Waals
CHEMBL5965059 Y125 4.41x41 TM4 hydrophobic
CHEMBL5965059 Y125 4.41x41 TM4 Van der Waals
CHEMBL5965059 I128 4.44x44 TM4 Van der Waals
CHEMBL5965059 A129 4.45x45 TM4 hydrophobic
CHEMBL5965059 A129 4.45x45 TM4 Van der Waals
CHEMBL4176503 C141 4.57x57 TM4 hydrophobic
CHEMBL4176503 V144 4.60x60 TM4 hydrophobic
CHEMBL4176503 I145 4.61x61 TM4 hydrophobic
CHEMBL4176503 V147 4.63x63 TM4 hydrophobic
CHEMBL4176503 Y165 45.51x51 ECL2 hydrophobic
CHEMBL4176503 V176 5.35x36 TM5 hydrophobic
CHEMBL4176503 V179 5.38x39 TM5 hydrophobic
CHEMBL4176503 R180 5.39x40 TM5 polar (charge-assisted hydrogen bond)
CHEMBL4176503 L183 5.42x43 TM5 Van der Waals
CHEMBL4176503 Y238 6.51x51 TM6 polar (hydrogen bond)
CHEMBL4176503 R255 7.35x34 TM7 polar (charge-assisted hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 P Q P ICL1ECL1 N F R W Y L ECL1ICL2 P V Q Y K L S R ICL2ECL2 T E Q V R S G N E I T C Y E N F T D N ECL2ICL3 P L V ICL3ECL3 K S P W ECL3N-term M L N-termC-term R N Q G S S L L G R R G K D T A E G T N E D R G V G Q G E G M P S S D F T T E C-term P D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R I R Q A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S P K V V C A L T S F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F R P L Y G V I A A L V A W V M S F G H C T I V I I V Q Y L N T Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L S Q G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G Y H Q R W R S I A V V F S S L N A S L D P L L F Y F S S S V F G R L V R R A G L Q V
Helix box plot — Download: PNG | SVG L N A P L G T L F I I I Y A M L I L S S 1 L S L T L A D L L L L L L L P F K I I E 2 G A L L W T S C Y I S S Y F G F S T L A 3 G V I A A L V A W V M S F G H C T I V I 4 Y C F I T V A M P I F F L V L C L E L R V 5 A V V T L L N F V L C F G P Y N V S H L V 6 L P D L S A N L S S F V V A I S R W 7

GPCRdb(A)
GPCRdb(A)
FFA2 receptor
TM3
3x30 3.30x30 F87
3x33 3.33x33 Y90
3x49 3.49x49 E106
3x52 3.52x52 L109
ICL2
34x53 34.53x53 Y117
34x56 34.56x56 S120
TM4
4x41 4.41x41 Y125
4x44 4.44x44 I128
4x45 4.45x45 A129
4x57 4.57x57 C141
4x60 4.60x60 V144
4x61 4.61x61 I145
4x63 4.63x63 V147
ECL2
45x51 45.51x51 Y165
TM5
5x36 5.35x36 V176
5x39 5.38x39 V179
5x40 5.39x40 R180
5x43 5.42x43 L183
TM6
6x51 6.51x51 Y238
TM7
7x34 7.35x34 R255