PDB
9ODF
Resolution
2.4 Å
Released
March 4, 2026
Receptor
μ
Class
A
Species
Mus musculus
Ligand
Function
LOFENTANIL
Agonist
Reference
10.1038/S41586-025-10056-4

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Ligand Amino Acid Generic Number Segment Interaction Type
LOFENTANIL Q124 2.60x60 TM2 hydrophobic
LOFENTANIL V143 3.28x28 TM3 hydrophobic
LOFENTANIL I144 3.29x29 TM3 hydrophobic
LOFENTANIL D147 3.32x32 TM3 polar (charge-charge)
LOFENTANIL D147 3.32x32 TM3 polar (hydrogen bond)
LOFENTANIL Y148 3.33x33 TM3 Van der Waals
LOFENTANIL M151 3.36x36 TM3 hydrophobic
LOFENTANIL C217 45.50x50 ECL2 hydrophobic
LOFENTANIL V236 5.42x43 TM5 Van der Waals
LOFENTANIL W293 6.48x48 TM6 hydrophobic
LOFENTANIL W293 6.48x48 TM6 aromatic (edge-to-face)
LOFENTANIL I296 6.51x51 TM6 Van der Waals
LOFENTANIL H297 6.52x52 TM6 Van der Waals
LOFENTANIL V300 6.55x55 TM6 Van der Waals
LOFENTANIL W318 7.35x34 TM7 Van der Waals
LOFENTANIL I322 7.39x38 TM7 Van der Waals
LOFENTANIL G325 7.42x41 TM7 Van der Waals
LOFENTANIL Y326 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x60 2.60x60 Q124
TM3
3x28 3.28x28 V143
3x29 3.29x29 I144
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x36 3.36x36 M151
ECL2
45x50 45.50x50 C217
TM5
5x43 5.42x43 V236
TM6
6x48 6.48x48 W293
6x51 6.51x51 I296
6x52 6.52x52 H297
6x55 6.55x55 V300
TM7
7x34 7.35x34 W318
7x38 7.39x38 I322
7x41 7.42x41 G325
7x42 7.43x42 Y326