PDB
9P0L
Resolution
3.1 Å
Released
April 29, 2026
Receptor
CXCR3
Class
A
Species
Homo sapiens
Ligand
CXCL10
Function
Agonist (partial)
Reference
10.1126/SCIADV.ADZ3767

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Ligand Amino Acid Generic Number Segment Interaction Type
CXCL10 T39 N-term polar (hydrogen bond with backbone)
CXCL10 T39 N-term polar (hydrogen bond)
CXCL10 T39 N-term polar (charge-assisted hydrogen bond)
CXCL10 S40 N-term polar (hydrogen bond with backbone)
CXCL10 S40 N-term polar (hydrogen bond)
CXCL10 P41 N-term polar (hydrogen bond)
CXCL10 P42 N-term polar (hydrogen bond)
CXCL10 C43 N-term polar (hydrogen bond)
CXCL10 P44 N-term Van der Waals
CXCL10 Q45 1.24x24 TM1 polar (hydrogen bond)
CXCL10 Q45 1.24x24 TM1 polar (hydrogen bond)
CXCL10 L49 1.28x28 TM1 Van der Waals
CXCL10 D52 1.31x31 TM1 polar (charge-assisted hydrogen bond)
CXCL10 D52 1.31x31 TM1 polar (charge-charge)
CXCL10 L56 1.35x35 TM1 polar (charge-assisted hydrogen bond)
CXCL10 Y60 1.39x39 TM1 polar (charge-assisted hydrogen bond)
CXCL10 Y60 1.39x39 TM1 polar (hydrogen bond)
CXCL10 L106 2.57x57 TM2 Van der Waals
CXCL10 W109 2.60x60 TM2 polar (hydrogen bond)
CXCL10 W109 2.60x60 TM2 polar (charge-assisted hydrogen bond)
CXCL10 D112 2.63x63 TM2 polar (hydrogen bond with backbone)
CXCL10 D112 2.63x63 TM2 polar (charge-assisted hydrogen bond)
CXCL10 A113 2.64x64 TM2 polar (hydrogen bond)
CXCL10 A113 2.64x64 TM2 polar (hydrogen bond with backbone)
CXCL10 A113 2.64x64 TM2 polar (charge-assisted hydrogen bond)
CXCL10 G128 3.29x29 TM3 Van der Waals
CXCL10 F131 3.32x32 TM3 hydrophobic
CXCL10 F131 3.32x32 TM3 Van der Waals
CXCL10 L190 4.64x65 TM4 Van der Waals
CXCL10 H193 ECL2 polar (hydrogen bond)
CXCL10 D195 ECL2 polar (charge-assisted hydrogen bond)
CXCL10 E196 ECL2 polar (charge-assisted hydrogen bond)
CXCL10 R197 ECL2 polar (charge-assisted hydrogen bond)
CXCL10 L198 ECL2 Van der Waals
CXCL10 H202 ECL2 Van der Waals
CXCL10 C203 45.50x50 ECL2 polar (hydrogen bond with backbone)
CXCL10 C203 45.50x50 ECL2 polar (hydrogen bond)
CXCL10 Q204 45.51x51 ECL2 polar (hydrogen bond)
CXCL10 Y205 45.52x52 ECL2 polar (hydrogen bond)
CXCL10 Y205 45.52x52 ECL2 polar (hydrogen bond with backbone)
CXCL10 N206 ECL2 polar (hydrogen bond with backbone)
CXCL10 N206 ECL2 polar (hydrogen bond)
CXCL10 F207 ECL2 polar (hydrogen bond with backbone)
CXCL10 F207 ECL2 Van der Waals
CXCL10 P208 5.31x32 TM5 polar (hydrogen bond)
CXCL10 Q209 5.32x33 TM5 polar (hydrogen bond)
CXCL10 R212 5.35x36 TM5 polar (hydrogen bond with backbone)
CXCL10 R212 5.35x36 TM5 polar (charge-assisted hydrogen bond)
CXCL10 L215 5.38x39 TM5 Van der Waals
CXCL10 L215 5.38x39 TM5 hydrophobic
CXCL10 R216 5.39x40 TM5 polar (charge-assisted hydrogen bond)
CXCL10 R216 5.39x40 TM5 polar (hydrogen bond with backbone)
CXCL10 Q219 5.42x43 TM5 polar (hydrogen bond)
CXCL10 Y271 6.51x51 TM6 Van der Waals
CXCL10 D278 6.58x58 TM6 polar (charge-assisted hydrogen bond)
CXCL10 D278 6.58x58 TM6 polar (charge-charge)
CXCL10 M281 6.61x61 TM6 Van der Waals
CXCL10 R288 ECL3 polar (charge-assisted hydrogen bond)
CXCL10 R288 ECL3 polar (hydrogen bond with backbone)
CXCL10 N289 7.24x23 TM7 Van der Waals
CXCL10 C290 7.25x24 TM7 Van der Waals
CXCL10 E293 7.28x27 TM7 polar (charge-assisted hydrogen bond)
CXCL10 V296 7.31x30 TM7 Van der Waals
CXCL10 D297 7.32x31 TM7 polar (charge-charge)
CXCL10 D297 7.32x31 TM7 polar (charge-assisted hydrogen bond)
CXCL10 K300 7.35x34 TM7 polar (charge-assisted hydrogen bond)
CXCL10 Y308 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 R T A L ICL1ECL1 Q W V F ECL1ICL2 A T Q L Y R R G P P ICL2ECL2 S A H H D E R L N A T H C Q Y N F ECL2ICL3 R G Q ICL3ECL3 A L A R ECL3N-term M V L E V S D H Q V L N D A E V A A L L E N F S S S Y D Y G E N E S D S C C T S P P C P N-termC-term G C P N Q R G L Q R Q P S S S R R D S S W S E T S E A S Y S G L C-term Q D F S L N F D R A F L P A L Y S L L F L L G L L G N G A V A A V L L S R S S T D T F L L H L A V A D T L L V L T L P L W A V D A A V G S G L C K V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A R V T L T C L A V W G L C L L F A L P D F I F L P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A V L L V S R R L R A M R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V K M W M L F R E R L L L R
Helix box plot — Download: PNG | SVG G N G L L G L L F L L S Y L A P L F A R 1 L H L A V A D T L L V L T L P L W A V D 2 C A L L L A G A Y F N I N F L A G A V K 3 V T L T C L A V W G L C L L F A L P D 4 Y C Y A M V L L P L L F G A V L Q L V R L 5 V V V V V A F A L C W T P Y H L V V L V 6 L P N L C C H M Y G L G S T V S K A V 7

GPCRdb(A)
GPCRdb(A)
CXCR3
TM1
1x24 1.24x24 Q45
1x28 1.28x28 L49
1x31 1.31x31 D52
1x35 1.35x35 L56
1x39 1.39x39 Y60
TM2
2x57 2.57x57 L106
2x60 2.60x60 W109
2x63 2.63x63 D112
2x64 2.64x64 A113
TM3
3x29 3.29x29 G128
3x32 3.32x32 F131
TM4
4x65 4.64x65 L190
ECL2
45x50 45.50x50 C203
45x51 45.51x51 Q204
45x52 45.52x52 Y205
TM5
5x32 5.31x32 P208
5x33 5.32x33 Q209
5x36 5.35x36 R212
5x39 5.38x39 L215
5x40 5.39x40 R216
5x43 5.42x43 Q219
TM6
6x51 6.51x51 Y271
6x58 6.58x58 D278
6x61 6.61x61 M281
TM7
7x23 7.24x23 N289
7x24 7.25x24 C290
7x27 7.28x27 E293
7x30 7.31x30 V296
7x31 7.32x31 D297
7x34 7.35x34 K300
7x42 7.43x42 Y308