PDB
9PA4
Resolution
2.5 Å
Released
July 1, 2026
Receptor
κ
Class
A
Species
Homo sapiens
Ligand
Function
ESKETAMINE
Agonist (partial)
Reference
10.1038/S41594-026-01839-Y

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Ligand Amino Acid Generic Number Segment Interaction Type
ESKETAMINE L135 3.29x29 TM3 Van der Waals
ESKETAMINE D138 3.32x32 TM3 hydrophobic
ESKETAMINE Y139 3.33x33 TM3 aromatic (edge-to-face)
ESKETAMINE Y139 3.33x33 TM3 hydrophobic
ESKETAMINE M142 3.36x36 TM3 hydrophobic
ESKETAMINE V230 5.42x43 TM5 hydrophobic
ESKETAMINE I290 6.51x51 TM6 hydrophobic
ESKETAMINE H291 6.52x52 TM6 aromatic (edge-to-face)
ESKETAMINE I294 6.55x55 TM6 hydrophobic
ESKETAMINE Y312 7.35x34 TM7 Van der Waals
ESKETAMINE I316 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
Helix box plot — Download: PNG | SVG S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7

GPCRdb(A)
GPCRdb(A)
κ receptor
TM3
3x29 3.29x29 I135
3x32 3.32x32 D138
3x33 3.33x33 Y139
3x36 3.36x36 M142
TM5
5x43 5.42x43 V230
TM6
6x51 6.51x51 I290
6x52 6.52x52 H291
6x55 6.55x55 I294
TM7
7x34 7.35x34 Y312
7x38 7.39x38 I316