| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| PF-07054894 | V67 | 1.53x53 | TM1 | hydrophobic |
| PF-07054894 | F71 | 1.57x57 | TM1 | hydrophobic |
| PF-07054894 | Y74 | 1.60x60 | TM1 | hydrophobic |
| PF-07054894 | S79 | 2.37x37 | TM2 | polar (hydrogen bond) |
| PF-07054894 | T81 | 2.39x39 | TM2 | polar (hydrogen bond) |
| PF-07054894 | T81 | 2.39x39 | TM2 | Van der Waals |
| PF-07054894 | D82 | 2.40x40 | TM2 | polar (charge-assisted hydrogen bond) |
| OXM2 | Y125 | 3.32x32 | TM3 | hydrophobic |
| OXM2 | A126 | 3.33x33 | TM3 | hydrophobic |
| OXM2 | F129 | 3.36x36 | TM3 | hydrophobic |
| OXM2 | N130 | 3.37x37 | TM3 | Van der Waals |
| OXM2 | N130 | 3.37x37 | TM3 | polar (hydrogen bond) |
| PF-07054894 | R143 | 3.50x50 | TM3 | Van der Waals |
| OXM2 | T182 | 4.60x61 | TM4 | Van der Waals |
| OXM2 | L215 | 5.39x40 | TM5 | Van der Waals |
| OXM2 | L215 | 5.39x40 | TM5 | hydrophobic |
| OXM2 | L219 | 5.43x44 | TM5 | Van der Waals |
| OXM2 | L219 | 5.43x44 | TM5 | hydrophobic |
| PF-07054894 | A364 | 6.33x33 | TM6 | hydrophobic |
| PF-07054894 | A364 | 6.33x33 | TM6 | Van der Waals |
| OXM2 | I380 | 6.49x49 | TM6 | Van der Waals |
| OXM2 | N383 | 6.52x52 | TM6 | polar (hydrogen bond) |
| OXM2 | N383 | 6.52x52 | TM6 | polar (hydrogen bond with backbone) |
| OXM2 | M384 | 6.53x53 | TM6 | Van der Waals |
| OXM2 | M384 | 6.53x53 | TM6 | polar (hydrogen bond with backbone) |
| OXM2 | L387 | 6.56x56 | TM6 | hydrophobic |
| OXM2 | L387 | 6.56x56 | TM6 | Van der Waals |
| PF-07054894 | Y428 | 7.53x53 | TM7 | hydrophobic |
| PF-07054894 | Y428 | 7.53x53 | TM7 | Van der Waals |
| PF-07054894 | K434 | 8.49x49 | H8 | Van der Waals |
| PF-07054894 | F435 | 8.50x50 | H8 | hydrophobic |
| PF-07054894 | F435 | 8.50x50 | H8 | Van der Waals |
| PF-07054894 | Y438 | 8.53x53 | H8 | Van der Waals |
| PF-07054894 | Y438 | 8.53x53 | H8 | hydrophobic |
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|
GPCRdb(A)
|
GPCRdb(A)
|
CCR6
|
|---|---|---|
| TM1 | ||
| 1x53 | 1.53x53 | V67 |
| 1x57 | 1.57x57 | F71 |
| 1x60 | 1.60x60 | Y74 |
| TM2 | ||
| 2x37 | 2.37x37 | S79 |
| 2x39 | 2.39x39 | T81 |
| 2x40 | 2.40x40 | D82 |
| TM3 | ||
| 3x32 | 3.32x32 | Y125 |
| 3x33 | 3.33x33 | A126 |
| 3x36 | 3.36x36 | F129 |
| 3x37 | 3.37x37 | N130 |
| 3x50 | 3.50x50 | R143 |
| TM4 | ||
| 4x61 | 4.60x61 | T182 |
| TM5 | ||
| 5x40 | 5.39x40 | L215 |
| 5x44 | 5.43x44 | L219 |
| TM6 | ||
| 6x33 | 6.33x33 | A252 |
| 6x49 | 6.49x49 | I268 |
| 6x52 | 6.52x52 | N271 |
| 6x53 | 6.53x53 | M272 |
| 6x56 | 6.56x56 | L275 |
| TM7 | ||
| 7x53 | 7.53x53 | Y316 |
| H8 | ||
| 8x49 | 8.49x49 | K322 |
| 8x50 | 8.50x50 | F323 |
| 8x53 | 8.53x53 | Y326 |