PDB
9PY3
Resolution
3.2 Å
Released
Nov. 12, 2025
Receptor
μ
Class
A
Species
Homo sapiens
Ligand
Function
loperamide
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
loperamide Q126 2.60x60 TM2 hydrophobic
loperamide Q126 2.60x60 TM2 polar (hydrogen bond)
loperamide N129 2.63x63 TM2 Van der Waals
loperamide W135 23.50x50 ECL1 hydrophobic
loperamide C142 3.25x25 TM3 Van der Waals
loperamide V145 3.28x28 TM3 hydrophobic
loperamide I146 3.29x29 TM3 hydrophobic
loperamide D149 3.32x32 TM3 polar (charge-charge)
loperamide Y150 3.33x33 TM3 polar (hydrogen bond)
loperamide Y150 3.33x33 TM3 hydrophobic
loperamide M153 3.36x36 TM3 hydrophobic
loperamide F154 3.37x37 TM3 hydrophobic
loperamide C219 45.50x50 ECL2 hydrophobic
loperamide V238 5.42x43 TM5 hydrophobic
loperamide W295 6.48x48 TM6 hydrophobic
loperamide I298 6.51x51 TM6 hydrophobic
loperamide H299 6.52x52 TM6 Van der Waals
loperamide V302 6.55x55 TM6 Van der Waals
loperamide I324 7.39x38 TM7 Van der Waals
loperamide G327 7.42x41 TM7 Van der Waals
loperamide Y328 7.43x42 TM7 aromatic (edge-to-face)
loperamide Y328 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x60 2.60x60 Q126
2x63 2.63x63 N129
ECL1
23x50 23.50x50 W135
TM3
3x25 3.25x25 C142
3x28 3.28x28 V145
3x29 3.29x29 I146
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
3x37 3.37x37 F154
ECL2
45x50 45.50x50 C219
TM5
5x43 5.42x43 V238
TM6
6x48 6.48x48 W295
6x51 6.51x51 I298
6x52 6.52x52 H299
6x55 6.55x55 V302
TM7
7x38 7.39x38 I324
7x41 7.42x41 G327
7x42 7.43x42 Y328