PDB
9U9V
Resolution
2.9 Å
Released
Sept. 3, 2025
Receptor
β2
Class
A
Species
Homo sapiens
Ligand
Function
METHAMPHETAMINE
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
METHAMPHETAMINE T110 3.29x29 TM3 hydrophobic
METHAMPHETAMINE D113 3.32x32 TM3 polar (charge-charge)
METHAMPHETAMINE V114 3.33x33 TM3 hydrophobic
METHAMPHETAMINE V117 3.36x36 TM3 hydrophobic
METHAMPHETAMINE F193 45.52x52 ECL2 Van der Waals
METHAMPHETAMINE S203 5.42x43 TM5 Van der Waals
METHAMPHETAMINE F289 6.51x51 TM6 hydrophobic
METHAMPHETAMINE F289 6.51x51 TM6 aromatic (edge-to-face)
METHAMPHETAMINE F290 6.52x52 TM6 aromatic (edge-to-face)
METHAMPHETAMINE N312 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 E R L Q ICL1ECL1 M W T F ECL1ICL2 P F K Y Q S L L ICL2ECL2 W Y R A T H Q E A I N C Y A N E T C C D F F T ECL2ICL3 G R F H V Q N L S Q V E Q D G R T G H G L R R S ICL3ECL3 D N L I ECL3N-term M G Q P G N G S A F L L A P N G S H A P D H D V T N-termC-term L R R S S L K A Y G N G Y S S N G N T G E Q S G Y H V E Q E K E N K L L C E D L P G T E D F V G H Q G T V P S D N I D S Q G R N C S T N D S L L C-term Q E R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S T K N K A R V I I L M V W I V S G L T S F L P I Q M H N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E S K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F Q E F R I A L L C
Helix box plot — Download: PNG | SVG V N G F V I A L V I L S M V I G M G V V 1 T S L A C A D L V M G A L V V P F G A A H 2 V C L T E I S A T V C L V D I S T W F E 3 A R V I I L M V W I V S G L T S F L P I 4 Y V F V M I V L P V Y F S V I S S A I A Y 5 G I I M G T F T L C W L P F F I V N I V 6 L P N F G S N V Y G I W N L L I Y V E 7

GPCRdb(A)
GPCRdb(A)
β2-adrenoceptor
TM3
3x29 3.29x29 T110
3x32 3.32x32 D113
3x33 3.33x33 V114
3x36 3.36x36 V117
ECL2
45x52 45.52x52 F193
TM5
5x43 5.42x43 S203
TM6
6x51 6.51x51 F289
6x52 6.52x52 F290
TM7
7x38 7.39x38 N312