PDB
9UJM
Resolution
3.1 Å
Released
April 29, 2026
Receptor
5-HT2A
Class
A
Species
Homo sapiens
Ligand
pimavanserin
Function
Inverse agonist
Reference
—

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
pimavanserin D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
pimavanserin V156 3.33x33 TM3 Van der Waals
pimavanserin V156 3.33x33 TM3 hydrophobic
pimavanserin S159 3.36x36 TM3 Van der Waals
pimavanserin T160 3.37x37 TM3 Van der Waals
pimavanserin I163 3.40x40 TM3 Van der Waals
pimavanserin I206 4.56x56 TM4 Van der Waals
pimavanserin I206 4.56x56 TM4 hydrophobic
pimavanserin P209 4.59x60 TM4 hydrophobic
pimavanserin P209 4.59x60 TM4 Van der Waals
pimavanserin I210 4.60x61 TM4 Van der Waals
pimavanserin I210 4.60x61 TM4 hydrophobic
pimavanserin L229 45.52x52 ECL2 hydrophobic
pimavanserin L229 45.52x52 ECL2 Van der Waals
pimavanserin G238 5.42x43 TM5 Van der Waals
pimavanserin S239 5.43x44 TM5 Van der Waals
pimavanserin S242 5.46x461 TM5 Van der Waals
pimavanserin F243 5.47x47 TM5 Van der Waals
pimavanserin F332 6.44x44 TM6 Van der Waals
pimavanserin W336 6.48x48 TM6 aromatic (face-to-edge)
pimavanserin W336 6.48x48 TM6 Van der Waals
pimavanserin F339 6.51x51 TM6 Van der Waals
pimavanserin F339 6.51x51 TM6 hydrophobic
pimavanserin F340 6.52x52 TM6 aromatic (edge-to-face)
pimavanserin F340 6.52x52 TM6 Van der Waals
pimavanserin V366 7.39x38 TM7 hydrophobic
pimavanserin V366 7.39x38 TM7 Van der Waals
pimavanserin Y370 7.43x42 TM7 polar (hydrogen bond)

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
Helix box plot — Download: PNG | SVG I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7

GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
3x37 3.37x37 T160
3x40 3.40x40 I163
TM4
4x56 4.56x56 I206
4x60 4.59x60 P209
4x61 4.60x61 I210
ECL2
45x52 45.52x52 L229
TM5
5x43 5.42x43 G238
5x44 5.43x44 S239
5x461 5.46x461 S242
5x47 5.47x47 F243
TM6
6x44 6.44x44 F332
6x48 6.48x48 W336
6x51 6.51x51 F339
6x52 6.52x52 F340
TM7
7x38 7.39x38 V366
7x42 7.43x42 Y370