PDB
9UMJ
Resolution
3.4 Å
Released
Nov. 26, 2025
Receptor
C3a
Class
A
Species
Mus musculus
Ligand
Function
EP54
Agonist
Reference
10.1101/2025.05.26.656101

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Ligand Amino Acid Generic Number Segment Interaction Type
EP54 H81 2.63x63 TM2 Van der Waals
EP54 W88 23.50x50 ECL1 Van der Waals
EP54 I98 3.28x28 TM3 Van der Waals
EP54 I102 3.32x32 TM3 hydrophobic
EP54 I103 3.33x33 TM3 Van der Waals
EP54 M106 3.36x36 TM3 hydrophobic
EP54 I165 ECL2 hydrophobic
EP54 I171 ECL2 hydrophobic
EP54 C172 45.50x50 ECL2 Van der Waals
EP54 R173 45.51x51 ECL2 aromatic (pi-cation)
EP54 Y174 45.52x52 ECL2 hydrophobic
EP54 R333 5.42x43 TM5 polar (hydrogen bond)
EP54 R333 5.42x43 TM5 polar (charge-charge)
EP54 Y386 6.51x51 TM6 hydrophobic
EP54 V389 6.54x54 TM6 Van der Waals
EP54 G390 6.55x55 TM6 Van der Waals
EP54 L393 6.58x58 TM6 Van der Waals
EP54 P398 ECL3 Van der Waals
EP54 M407 7.32x31 TM7 Van der Waals
EP54 D410 7.35x34 TM7 polar (hydrogen bond)
EP54 D410 7.35x34 TM7 polar (charge-charge)
EP54 H411 7.36x35 TM7 Van der Waals
EP54 S413 7.38x37 TM7 Van der Waals
EP54 I414 7.39x38 TM7 hydrophobic

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ICL1 M K T ICL1ECL1 G H W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 D L F I M D N R S I C R Y N F D S S R S Y D Y W D Y V Y K L S L P E S N S T D N S T A Q L T G H M N D R S A P S S V Q A R D Y F W T V T T A L Q S Q P F L T S P E D S F S L D S A N Q Q P H Y G G K P P N V L T A A V P S G F P V E D R K S N T L N A D A F L S A H T E L F P T A S S G H L Y P Y D F Q G D Y V D Q F T Y D N H ECL2ICL3 T N F T K S R ICL3ECL3 D P E ECL3N-term M E S F D A D T N S T D L H S R P L F N-termC-term S I K G I L E A A F S E E L T H S T N C T Q D K A S S K R N N M S T D V C-term Q P Q D I A S M V I L G L T C L L G L L G N G L V L W V A G V K T V N T V W F L H L T L A D F L C C L S L P F S L A H L I L Q G L F L C K L I P S I I I L N M F A S V F L L T A I S L D R C L I V H K N V R T A F A I C G C V W V V A F V M C V P V F V Y R V P T P L M A I T I T R L V V G F L V P F F I M V I C Y S L I V F R M R K N K T F R V A V A V V T V F F I C W T P Y H L V G V L L L I T S S L G E A V M S W D H M S I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
Helix box plot — Download: PNG | SVG G N G L L G L L C T L G L I V M S A I D 1 L H L T L A D F L C C L S L P F S L A H 2 A T L L F V S A F M N L I I I S P I L K 3 A F A I C G C V W V V A F V M C V P V 4 Y C I V M I F F P V L F G V V L R T I T I 5 V A V V T V F F I C W T P Y H L V G V L 6 F P N F C S N A S A L A I S M H D W S 7

GPCRdb(A)
GPCRdb(A)
C3a receptor
TM2
2x63 2.63x63 H81
ECL1
23x50 23.50x50 W88
TM3
3x28 3.28x28 I98
3x32 3.32x32 I102
3x33 3.33x33 I103
3x36 3.36x36 M106
ECL2
45x50 45.50x50 C172
45x51 45.51x51 R173
45x52 45.52x52 Y174
TM5
5x43 5.42x43 R333
TM6
6x51 6.51x51 Y386
6x54 6.54x54 V389
6x55 6.55x55 G390
6x58 6.58x58 L393
TM7
7x31 7.32x31 M407
7x34 7.35x34 D410
7x35 7.36x35 H411
7x37 7.38x37 S413
7x38 7.39x38 I414