Biased Signaling Atlas

Ligand	Amino Acid	Generic Number	Segment	Interaction Type


C5a-pep	L92	2.60x60	TM2	hydrophobic
C5a-pep	W102	23.50x50	ECL1	Van der Waals
C5a-pep	I116	3.32x32	TM3	hydrophobic
C5a-pep	L117	3.33x33	TM3	Van der Waals
C5a-pep	R175		ECL2	polar (hydrogen bond)
C5a-pep	R175		ECL2	polar (charge-charge)
C5a-pep	R178		ECL2	hydrophobic
C5a-pep	L187		ECL2	hydrophobic
C5a-pep	C188	45.50x50	ECL2	Van der Waals
C5a-pep	G189	45.51x51	ECL2	Van der Waals
C5a-pep	V190	45.52x52	ECL2	polar (hydrogen bond with backbone)
C5a-pep	V190	45.52x52	ECL2	hydrophobic
C5a-pep	D191		ECL2	polar (charge-charge)
C5a-pep	E199	5.35x36	TM5	polar (charge-charge)
C5a-pep	R206	5.42x43	TM5	polar (hydrogen bond)
C5a-pep	R206	5.42x43	TM5	polar (charge-charge)
C5a-pep	Y258	6.51x51	TM6	Van der Waals
C5a-pep	G262	6.55x55	TM6	Van der Waals
C5a-pep	M265	6.58x58	TM6	hydrophobic
C5a-pep	M265	6.58x58	TM6	polar (hydrogen bond with backbone)
C5a-pep	S266	6.59x59	TM6	Van der Waals
C5a-pep	L268	6.61x61	TM6	Van der Waals
C5a-pep	P270		ECL3	Van der Waals
C5a-pep	F275	7.28x27	TM7	hydrophobic
C5a-pep	K279	7.32x31	TM7	polar (hydrogen bond)
C5a-pep	D282	7.35x34	TM7	polar (charge-charge)
C5a-pep	D282	7.35x34	TM7	polar (hydrogen bond)
C5a-pep	V286	7.39x38	TM7	Van der Waals