PDB
9UPO
Resolution
3.7 Å
Released
June 24, 2026
Receptor
OPN1MW3
Class
A
Species
Macaca fascicularis
Ligand
all-trans-retinal
Function
Inverse agonist
Reference
10.1126/SCIENCE.ADZ3996

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Ligand Amino Acid Generic Number Segment Interaction Type
all-trans-retinal V133 3.32x32 TM3 hydrophobic
all-trans-retinal I138 3.37x37 TM3 hydrophobic
all-trans-retinal C203 45.50x50 ECL2 hydrophobic
all-trans-retinal W363 6.48x48 TM6 hydrophobic
all-trans-retinal Y366 6.51x51 TM6 hydrophobic
all-trans-retinal A367 6.52x52 TM6 hydrophobic
all-trans-retinal A390 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K K L R ICL1ECL1 Y F V ECL1ICL2 P F G N V R F ICL2ECL2 P P I F G W S R Y W P H G L K T S C G P D V F S G S S ECL2ICL3 K E ICL3ECL3 P G Y A F ECL3N-term M A Q Q W S L Q R L A G R H P Q D S Y E D S T Q S S I F T Y T N S N S T R G P F E G P N Y H I A N-termC-term G K K V D D G S E L S S A S K T E V S S V S S V S P A C-term P R W V Y H L T S V W M I F V V I A S V F T N G L V L A A T M K F H P L N W I L V N L A V A D L A E T V I A S T I S V V N Q V Y G L G H P M C V L E G Y T V S L C G I T G L W S L A I I S W E R W M V V C K D A K L A I V G I V F S W V W A A V W T A Y P G V Q S Y M I V L M V T C C I T P L T I I V L C Y L Q V W L A I R A V A K Q Q S E S T Q K A E K E V T R M V V V M F L A F C F C W G P Y A F F A C F A A A N H P L M A A L P A Y F A K S A T I Y N P I I Y V F M N R Q F L Q L R N C I F
Helix box plot — Download: PNG | SVG G N T F V S A I V V F I M W V S T L H Y 1 V N L A V A D L A E T I V A S T I S V V N 2 I A L S W L G T I G C L S V T Y G E L V 3 A I V G I V F S W V W A A V W T A 4 Y C L V I I T L P T I C C T V M L V I M Y 5 V V M F L A F C F C W G P Y A F F A C F 6 I P N Y I T A S K A F Y A P L A A M L 7

GPCRdb(A)
GPCRdb(A)
OPN1MW3
TM3
3x32 3.32x32 V133
3x37 3.37x37 I138
ECL2
45x50 45.50x50 C203
TM6
6x48 6.48x48 W281
6x51 6.51x51 Y284
6x52 6.52x52 A285
TM7
7x38 7.39x38 A308