PDB
9UPO
Resolution
3.7 Å
Released
June 24, 2026
Receptor
OPN1MW3
Class
A
Species
Macaca fascicularis
Ligand
Function
all-trans-retinal
Inverse agonist
Reference
10.1126/SCIENCE.ADZ3996

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Ligand Amino Acid Generic Number Segment Interaction Type
all-trans-retinal E129 3.28x28 TM3 Van der Waals
all-trans-retinal V133 3.32x32 TM3 hydrophobic
all-trans-retinal S134 3.33x33 TM3 Van der Waals
all-trans-retinal G137 3.36x36 TM3 Van der Waals
all-trans-retinal I138 3.37x37 TM3 hydrophobic
all-trans-retinal L141 3.40x40 TM3 hydrophobic
all-trans-retinal C203 45.50x50 ECL2 Van der Waals
all-trans-retinal P205 45.52x52 ECL2 hydrophobic
all-trans-retinal L223 5.42x43 TM5 hydrophobic
all-trans-retinal C227 5.46x461 TM5 hydrophobic
all-trans-retinal W363 6.48x48 TM6 hydrophobic
all-trans-retinal Y366 6.51x51 TM6 hydrophobic
all-trans-retinal A367 6.52x52 TM6 hydrophobic
all-trans-retinal A390 7.39x38 TM7 hydrophobic
all-trans-retinal A393 7.42x41 TM7 Van der Waals
all-trans-retinal K394 7.43x42 TM7 covalent bond

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Snake plot — Download: PNG | SVG
ICL1 K K L R ICL1ECL1 Y F V ECL1ICL2 P F G N V R F ICL2ECL2 P P I F G W S R Y W P H G L K T S C G P D V F S G S S ECL2ICL3 K E ICL3ECL3 P G Y A F ECL3N-term M A Q Q W S L Q R L A G R H P Q D S Y E D S T Q S S I F T Y T N S N S T R G P F E G P N Y H I A N-termC-term G K K V D D G S E L S S A S K T E V S S V S S V S P A C-term P R W V Y H L T S V W M I F V V I A S V F T N G L V L A A T M K F H P L N W I L V N L A V A D L A E T V I A S T I S V V N Q V Y G L G H P M C V L E G Y T V S L C G I T G L W S L A I I S W E R W M V V C K D A K L A I V G I V F S W V W A A V W T A Y P G V Q S Y M I V L M V T C C I T P L T I I V L C Y L Q V W L A I R A V A K Q Q S E S T Q K A E K E V T R M V V V M F L A F C F C W G P Y A F F A C F A A A N H P L M A A L P A Y F A K S A T I Y N P I I Y V F M N R Q F L Q L R N C I F
Helix box plot — Download: PNG | SVG G N T F V S A I V V F I M W V S T L H Y 1 V N L A V A D L A E T I V A S T I S V V N 2 I A L S W L G T I G C L S V T Y G E L V 3 A I V G I V F S W V W A A V W T A 4 Y C L V I I T L P T I C C T V M L V I M Y 5 V V M F L A F C F C W G P Y A F F A C F 6 I P N Y I T A S K A F Y A P L A A M L 7

GPCRdb(A)
GPCRdb(A)
OPN1MW3
TM3
3x28 3.28x28 E129
3x32 3.32x32 V133
3x33 3.33x33 S134
3x36 3.36x36 G137
3x37 3.37x37 I138
3x40 3.40x40 L141
ECL2
45x50 45.50x50 C203
45x52 45.52x52 P205
TM5
5x43 5.42x43 L223
5x461 5.46x461 C227
TM6
6x48 6.48x48 W281
6x51 6.51x51 Y284
6x52 6.52x52 A285
TM7
7x38 7.39x38 A308
7x41 7.42x41 A311
7x42 7.43x42 K312