PDB
9UTB
Resolution
3.6 Å
Released
July 16, 2025
Receptor
TAS1R2
Class
C
Species
Homo sapiens
Ligand
Function
Sucralose
Agonist
Reference
10.1038/S41586-025-09302-6

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Ligand Amino Acid Generic Number Segment Interaction Type
Sucralose S40 N-term Van der Waals
Sucralose K65 N-term hydrophobic
Sucralose Y103 N-term hydrophobic
Sucralose D142 N-term Van der Waals
Sucralose Y215 N-term hydrophobic
Sucralose E302 N-term Van der Waals
Sucralose S303 N-term polar (hydrogen bond)

NGL is a WebGL based 3D viewer powered by MMTF.

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Snake plot — Download: PNG | SVG
ICL1 T F Q P I V R S A ICL1ECL1 G P P ECL1ICL2 K M A S R F P R A Y S Y W V ICL2ECL2 G L S P T T R T D P D D P K I T I V S C N P N Y ECL2ICL3 P T N Y ICL3ECL3 S ECL3N-term M G P R A K T I S S L F F L L W V L A E P A E N S D F Y L P G D Y L L G G L F S L H A N M K G I V H L N F L Q V P M C K E Y E V K V I G Y N L M Q A M R F A V E E I N N D S S L L P G V L L G Y E I V D V C Y I S N N V Q P V L Y F L A H E D N L L P I Q E D Y S N Y I S R V V A V I G P D N S E S V M T V A N F L S L F L L P Q I T Y S A I S D E L R D K V R F P A L L R T T P S A D H H I E A M V Q L M L H F R W N W I I V L V S S D T Y G R D N G Q L L G E R V A R R D I C I A F Q E T L P T L Q P N Q N M T S E E R Q R L V T I V D K L Q Q S T A R V V V V F S P D L T L Y H F F N E V L R Q N F T G A V W I A S E S W A I D P V L H N L T E L R H L G T F L G I T I Q S V P I P G F S E F R E W G P Q A G P P P L S R T S Q S Y T C N Q E C D N C L N A T L S F N T I L R L S G E R V V Y S V Y S A V Y A V A H A L H S L L G C D K S T C T K R V V Y P W Q L L E E I W K V N F T L L D H Q I F F D P Q G D V A L H L E I V Q W Q W D R S Q N P F Q S V A S Y Y P L Q R Q L K N I Q D I S W H T I N N T I P M S M C S K R C Q S G Q K K K P V G I H V C C F E C I D C L P G T F L N H T E D E Y E C Q A C P N N E W S Y Q S E T S C F K R Q L V F L E W H N-termC-term I Q G Y T M R R D C-term E A P T I A V A L L A A L G F L S T L A I L V I F W R H G G P M C F L M L T L L L V A Y M V V P V Y V K V S T C L C R Q A L F P L C F T I C I S C I A V R S F Q I V C A F R Y Q G P Y V S M A F I T V L K M V I V V I G M L A T R N S L L F N T S L D L L L S V V G F S F A Y M G K E L N E A K F I T L S M T F Y F T S S V S L C T F M S A Y G V L V T I V D L L V T V L N L L A I S L G Y F G P K C Y M I L F Y P E R Y F N N T P A S M
Helix box plot — Download: PNG | SVG L T S L F G L A A L L A V A I T P A E 1 F L M L T L L L V A Y M V V P V Y V 2 V A I C S I C I T F C L P F L A Q R C L 3 P Y V S M A F I T V L K M V I V V I G M 4 A F S F G V V S L L L D L S T N F L L S 5 T L S M T F Y F T S S V S L C T F M S A 6 L S I A L L N L V T V L L D V I T V L V 7

GPCRdb(A)
GPCRdb(C)
TAS1R2