PDB
9UXU
Resolution
3.6 Å
Released
May 27, 2026
Receptor
κ
Class
A
Species
Homo sapiens
Ligand
salvinorin A
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
salvinorin A V134 3.28x28 TM3 hydrophobic
salvinorin A I135 3.29x29 TM3 hydrophobic
salvinorin A D138 3.32x32 TM3 polar (charge-assisted hydrogen bond)
salvinorin A Y139 3.33x33 TM3 Van der Waals
salvinorin A Y139 3.33x33 TM3 hydrophobic
salvinorin A M142 3.36x36 TM3 hydrophobic
salvinorin A M142 3.36x36 TM3 Van der Waals
salvinorin A C210 45.50x50 ECL2 Van der Waals
salvinorin A W287 6.48x48 TM6 Van der Waals
salvinorin A W287 6.48x48 TM6 hydrophobic
salvinorin A I290 6.51x51 TM6 hydrophobic
salvinorin A I290 6.51x51 TM6 Van der Waals
salvinorin A I294 6.55x55 TM6 Van der Waals
salvinorin A I294 6.55x55 TM6 hydrophobic
salvinorin A Y312 7.35x34 TM7 Van der Waals
salvinorin A I316 7.39x38 TM7 hydrophobic
salvinorin A I316 7.39x38 TM7 Van der Waals
salvinorin A G319 7.42x41 TM7 Van der Waals
salvinorin A Y320 7.43x42 TM7 hydrophobic
salvinorin A Y320 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
Helix box plot — Download: PNG | SVG S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7

GPCRdb(A)
GPCRdb(A)
κ receptor
TM3
3x28 3.28x28 V134
3x29 3.29x29 I135
3x32 3.32x32 D138
3x33 3.33x33 Y139
3x36 3.36x36 M142
ECL2
45x50 45.50x50 C210
TM6
6x48 6.48x48 W287
6x51 6.51x51 I290
6x55 6.55x55 I294
TM7
7x34 7.35x34 Y312
7x38 7.39x38 I316
7x41 7.42x41 G319
7x42 7.43x42 Y320