PDB
9V0X
Resolution
2.7 Å
Released
Feb. 4, 2026
Receptor
PrRP
Class
A
Species
Homo sapiens
Ligands
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]
GUB08248
Function
Agonist
Agonist
Reference
10.1038/S41401-025-01741-1
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] GUB08248

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Ligand Amino Acid Generic Number Segment Interaction Type
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] Q54 N-term Van der Waals
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] V56 N-term hydrophobic
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] V56 N-term Van der Waals
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] H57 N-term Van der Waals
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] H57 N-term polar (hydrogen bond)
GUB08248 Y120 2.64x63 TM2 polar (hydrogen bond with backbone)
GUB08248 Y120 2.64x63 TM2 polar (hydrogen bond)
GUB08248 Y120 2.64x63 TM2 Van der Waals
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] A121 2.65x64 TM2 Van der Waals
GUB08248 A121 2.65x64 TM2 Van der Waals
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] A121 2.65x64 TM2 polar (hydrogen bond with backbone)
GUB08248 E123 2.67x66 TM2 Van der Waals
GUB08248 E123 2.67x66 TM2 polar (hydrogen bond with backbone)
GUB08248 P124 ECL1 polar (hydrogen bond with backbone)
GUB08248 P124 ECL1 Van der Waals
GUB08248 G126 23.49x49 ECL1 Van der Waals
GUB08248 F138 3.29x29 TM3 Van der Waals
GUB08248 F138 3.29x29 TM3 hydrophobic
GUB08248 Q141 3.32x32 TM3 Van der Waals
GUB08248 P142 3.33x33 TM3 Van der Waals
GUB08248 P142 3.33x33 TM3 hydrophobic
GUB08248 V145 3.36x36 TM3 Van der Waals
GUB08248 V145 3.36x36 TM3 hydrophobic
GUB08248 Y146 3.37x37 TM3 Van der Waals
GUB08248 Y146 3.37x37 TM3 hydrophobic
GUB08248 L210 ECL2 Van der Waals
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] L210 ECL2 Van der Waals
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] L210 ECL2 hydrophobic
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] E212 45.51x51 ECL2 polar (charge-assisted hydrogen bond)
GUB08248 E212 45.51x51 ECL2 Van der Waals
GUB08248 E213 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] F214 ECL2 hydrophobic
GUB08248 L294 6.51x51 TM6 Van der Waals
GUB08248 N298 6.55x55 TM6 Van der Waals
GUB08248 R301 6.58x58 TM6 Van der Waals
GUB08248 D302 6.59x59 TM6 Van der Waals
GUB08248 P310 7.28x27 TM7 Van der Waals
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] P310 7.28x27 TM7 Van der Waals
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] P310 7.28x27 TM7 hydrophobic
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] Y311 7.29x28 TM7 hydrophobic
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] Y311 7.29x28 TM7 Van der Waals
GUB08248 F313 7.31x30 TM7 Van der Waals
GUB08248 F313 7.31x30 TM7 hydrophobic
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] F313 7.31x30 TM7 hydrophobic
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] F313 7.31x30 TM7 Van der Waals
KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] G314 7.32x31 TM7 Van der Waals
GUB08248 Q317 7.35x34 TM7 polar (hydrogen bond)
GUB08248 Q317 7.35x34 TM7 Van der Waals
GUB08248 H321 7.39x38 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 R R L H ICL1ECL1 R G W V F ECL1ICL2 P L R R R I ICL2ECL2 Y H V E L K P H D V R L C E E F W G S Q ECL2ICL3 V T Q S Q ICL3ECL3 P H A I ECL3N-term M A S S T T R G P R V S D L F S G L P P A V T T P A N Q S A E A S A G N G S V A G A D A P A V T P F Q S L Q L V H Q N-termC-term K I A P H G Q N M T V S V V I C-term L K G L I V L L Y S V V V V V G L V G N C L L V L V I A R V N V T N F L I G N L A L S D V L M C T A C V P L T L A Y A F E P G G G L C H L V F F L Q P V T V Y V S V F T L T T I A V D R Y V V L V H S L R L S A Y A V L A I W A L S A V L A L P A A V H T E R Q R Q L Y A W G L L L V T Y L L P L L V I L L S Y V R V S V K L R N R V V P G C A D W D R A R R R R T F C L L V V I V V V F A V C W L P L H V F N L L R D L D D P Y A F G L V Q L L C H W L A M S S A C Y N P F I Y A W L H D S L R K W P R F R E E L L V A
Helix box plot — Download: PNG | SVG C N G V L G V V V V V S Y L L V I L G K 1 G N L A L S D V L M C A T C V P L T L A Y 2 T T L T F V S V Y V T V P Q L F F V L H 3 S A Y A V L A I W A L S A V L A L P A 4 Y S L L I V L L P L L Y T V L L L G W A Y 5 V V I V V V F A V C W L P L H V F N L L 6 F P N Y C A S S M A L W H C L L Q V L 7

GPCRdb(A)
GPCRdb(A)
PrRP receptor
TM2
2x63 2.64x63 Y120
2x64 2.65x64 A121
2x66 2.67x66 E123
ECL1
23x49 23.49x49 G126
TM3
3x29 3.29x29 F138
3x32 3.32x32 Q141
3x33 3.33x33 P142
3x36 3.36x36 V145
3x37 3.37x37 Y146
ECL2
45x51 45.51x51 E212
45x52 45.52x52 E213
TM6
6x51 6.51x51 L294
6x55 6.55x55 N298
6x58 6.58x58 R301
6x59 6.59x59 D302
TM7
7x27 7.28x27 P310
7x28 7.29x28 Y311
7x30 7.31x30 F313
7x31 7.32x31 G314
7x34 7.35x34 Q317
7x38 7.39x38 H321