PDB
9VIF
Resolution
3.2 Å
Released
Dec. 3, 2025
Receptor
NPFF1
Class
A
Species
Homo sapiens
Ligand
Function
neuropeptide FF (Human)
Agonist
Reference
10.1093/PROCEL/PWAF090

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Ligand Amino Acid Generic Number Segment Interaction Type
neuropeptide FF (Human) S33 N-term Van der Waals
neuropeptide FF (Human) Q37 N-term Van der Waals
neuropeptide FF (Human) D103 2.64x63 TM2 Van der Waals
neuropeptide FF (Human) N104 2.65x64 TM2 Van der Waals
neuropeptide FF (Human) T107 ECL1 Van der Waals
neuropeptide FF (Human) W109 23.50x50 ECL1 Van der Waals
neuropeptide FF (Human) G120 3.29x29 TM3 Van der Waals
neuropeptide FF (Human) Q123 3.32x32 TM3 Van der Waals
neuropeptide FF (Human) G124 3.33x33 TM3 Van der Waals
neuropeptide FF (Human) V127 3.36x36 TM3 Van der Waals
neuropeptide FF (Human) S176 4.60x61 TM4 polar (hydrogen bond)
neuropeptide FF (Human) L200 ECL2 Van der Waals
neuropeptide FF (Human) E205 45.52x52 ECL2 polar (hydrogen bond)
neuropeptide FF (Human) E205 45.52x52 ECL2 polar (charge-charge)
neuropeptide FF (Human) T217 5.39x40 TM5 Van der Waals
neuropeptide FF (Human) L220 5.42x43 TM5 hydrophobic
neuropeptide FF (Human) L286 6.51x51 TM6 Van der Waals
neuropeptide FF (Human) W287 6.52x52 TM6 hydrophobic
neuropeptide FF (Human) L290 6.55x55 TM6 hydrophobic
neuropeptide FF (Human) I293 6.58x58 TM6 Van der Waals
neuropeptide FF (Human) T307 7.31x30 TM7 Van der Waals
neuropeptide FF (Human) F311 7.35x34 TM7 Van der Waals
neuropeptide FF (Human) H315 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R H M H ICL1ECL1 G W P F ECL1ICL2 P F R E K L ICL2ECL2 T V T R E E H H F M V D A R N R S Y P L Y S C W E A W P E K ECL2ICL3 G G E E A ICL3ECL3 Q L S A P Q L ECL3N-term M E G E P S Q P P N S S W P L S Q N G T N T E A T P A T N L T F S S Y Y Q H T S P V N-termC-term P R P S G S H K E A Y S E R P G G L L H R R V F V V V R P S D S G L P S E S G P S S G A P R P G R L P L R N G R V A H H G L P R E G P G C S H L P L T I P A W D I C-term A A M F I V A Y A L I F L L C M V G N T L V C F I V L K N T V T N M F I L N L A V S D L L V G I F C M P T T L V D N L I T D N A T C K M S G L V Q G M S V S A S V F T L V A I A V E R F R C I V H T L R K A L V T I A V I W A L A L L I M C P S A V T L G M R R V Y T T V L F S H I Y L A P L A L I V V M Y A R I A R K L C Q A P G P A P A D P R A S R R R A R V V H M L V M V A L F F T L S W L P L W A L L L L I D Y G H L V T V Y A F P F A H W L A F F N S S A N P I I Y G Y F N E N F Q A R L C F R R G A F R A
Helix box plot — Download: PNG | SVG T N G V M C L L F I L A Y A V I F M A A 1 L N L A V S D L L V G F I C M P T T L V D 2 A V L T F V S A S V S M G Q V L G S M K 3 A L V T I A V I W A L A L L I M C P S 4 Y M V V I L A L P A L Y I H S F L V T T Y 5 V M V A L F F T L S W L P L W A L L L L 6 I P N A S S N F F A L W H A F P F A Y 7

GPCRdb(A)
GPCRdb(A)
NPFF1 receptor
TM2
2x63 2.64x63 D103
2x64 2.65x64 N104
ECL1
23x50 23.50x50 W109
TM3
3x29 3.29x29 G120
3x32 3.32x32 Q123
3x33 3.33x33 G124
3x36 3.36x36 V127
TM4
4x61 4.60x61 S176
ECL2
45x52 45.52x52 E205
TM5
5x40 5.39x40 T217
5x43 5.42x43 L220
TM6
6x51 6.51x51 L286
6x52 6.52x52 W287
6x55 6.55x55 L290
6x58 6.58x58 I293
TM7
7x30 7.31x30 T307
7x34 7.35x34 F311
7x38 7.39x38 H315