PDB
9VJ5
Resolution
2.7 Å
Released
Nov. 12, 2025
Receptor
5-HT1A
Class
A
Species
Homo sapiens
Ligand
GEPIRONE
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
GEPIRONE A93 2.61x60 TM2 Van der Waals
GEPIRONE A93 2.61x60 TM2 polar (hydrogen bond with backbone)
GEPIRONE Y96 2.64x63 TM2 Van der Waals
GEPIRONE Y96 2.64x63 TM2 hydrophobic
GEPIRONE Q97 2.65x64 TM2 Van der Waals
GEPIRONE D116 3.32x32 TM3 polar (charge-assisted hydrogen bond)
GEPIRONE V117 3.33x33 TM3 Van der Waals
GEPIRONE V117 3.33x33 TM3 hydrophobic
GEPIRONE C120 3.36x36 TM3 Van der Waals
GEPIRONE T121 3.37x37 TM3 Van der Waals
GEPIRONE I189 45.52x52 ECL2 Van der Waals
GEPIRONE S199 5.42x43 TM5 Van der Waals
GEPIRONE A203 5.46x461 TM5 Van der Waals
GEPIRONE W358 6.48x48 TM6 Van der Waals
GEPIRONE W358 6.48x48 TM6 hydrophobic
GEPIRONE F361 6.51x51 TM6 hydrophobic
GEPIRONE F361 6.51x51 TM6 Van der Waals
GEPIRONE F362 6.52x52 TM6 hydrophobic
GEPIRONE F362 6.52x52 TM6 Van der Waals
GEPIRONE N386 7.39x38 TM7 Van der Waals
GEPIRONE Y390 7.43x42 TM7 polar (hydrogen bond)

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ICL1 R S L Q ICL1ECL1 K W T L ECL1ICL2 P I D Y V N K R ICL2ECL2 R T P E D R S D P D A C T I S K ECL2ICL3 E K T G A D T R H G A S P A P Q P K K S V N G E S G S R N W R L G V E S K A G G A L C A N G A V R Q G D D G A A L E V I E V H R V G N S K E H L P L P S E A G P T P C A P A S F E R ICL3ECL3 E S S C H M ECL3N-term M D V L S P G Q G N N T T S P P A P F E T G G N T T G I S D V N-termC-term K C K F C R Q C-term T V S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N G Q V T C D L F I A L D V L C C T S S I L H L C A I A L D R Y W A I T D T P R R A A A L I S L T W L I G F L I S I P P M L G W D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K T V K K V K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F K K F Q N A I I
Helix box plot — Download: PNG | SVG A N G L V A C F I L T G L L L S T I V Q 1 G S L A V T D L M V S L V V L P M A A L Y 2 A C L H L I S S T C C L V D L A I F L D 3 A A A L I S L T W L I G F L I S I P P M 4 Y L V L M L L L P I Y F A G F T S Y I T Y 5 G I I M G T F I L C W L P F F I V A L V 6 V P N L L S N S Y G L W N I I A G L L 7

GPCRdb(A)
GPCRdb(A)
5-HT1A receptor
TM2
2x60 2.61x60 A93
2x63 2.64x63 Y96
2x64 2.65x64 Q97
TM3
3x32 3.32x32 D116
3x33 3.33x33 V117
3x36 3.36x36 C120
3x37 3.37x37 T121
ECL2
45x52 45.52x52 I189
TM5
5x43 5.42x43 S199
5x461 5.46x461 A203
TM6
6x48 6.48x48 W358
6x51 6.51x51 F361
6x52 6.52x52 F362
TM7
7x38 7.39x38 N386
7x42 7.43x42 Y390