PDB
9W0T
Resolution
3.3 Å
Released
April 22, 2026
Receptor
TAS2R46
Class
T2
Species
Homo sapiens
Ligand
Function
denatonium
Agonist
Reference
10.1038/S41594-026-01786-8

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Ligand Amino Acid Generic Number Segment Interaction Type
denatonium L62 2.57x57 TM2 hydrophobic
denatonium N65 2.60x60 TM2 hydrophobic
denatonium T69 2.64x64 TM2 Van der Waals
denatonium Y85 3.29x29 TM3 hydrophobic
denatonium Y85 3.29x29 TM3 aromatic (edge-to-face)
denatonium W88 3.32x32 TM3 aromatic (pi-cation)
denatonium W88 3.32x32 TM3 hydrophobic
denatonium N176 5.39x40 TM5 Van der Waals
denatonium T180 5.43x44 TM5 hydrophobic
denatonium F261 7.35x34 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K I ICL1ECL1 P A F N ECL1ICL2 N F S N L I F L H L K R ICL2ECL2 I W T K E Y E G N M T W K I K L R S A M Y L S ECL2ICL3 K G S Q ICL3ECL3 L E N ECL3N-term M N-termC-term K G E K P S S S C-term I T F L P I I F S I L I V V T F V I G N F A N G F I A L V N S I E W F K R Q S F A D Q I L T A L A V S R V G L L W V L V L N W Y A T E L N S I E V R I T A Y N V W A V I N H F S N W L A T S L S I F Y L L K I A R V K S V V L V I L L G P L L F L V C H L F V I N M N Q I N T T V T I L A N L V P F T L T L I S F L L L I C S L C K H L K K M Q L H G D P S M K V H I K A L Q T V T S F L L L C A I Y F L S I I M S V W S F E S K P V F M F C E A I A F S Y P S T H P F I L I W G N K K F L S V R Y L K Q T V L W H W V
Helix box plot — Download: PNG | SVG G N A F N G I V F T V V I L I S F I I P 1 T A L A V S R V G L L W V L V L N W Y A 2 S T A L W N S F H N I V A W V N Y A T I 3 V L V I L L G P L L F L V C H L F V I N 4 F S I L T L T F P V L N A L I T V T T N 5 V T S F L L L C A I Y F L S I I M S V W 6 F P H T S P Y S F A I A E C F M F V P 7

GPCRdb(A)
GPCRdb(A)
TAS2R46
TM2
2x57 2.57x57 L62
2x60 2.60x60 N65
2x64 2.64x64 T69
TM3
3x29 3.29x29 Y85
3x32 3.32x32 W88
TM5
5x40 5.39x40 N176
5x44 5.43x44 T180
TM7
7x34 7.35x34 F261