PDB
9W0U
Resolution
2.9 Å
Released
April 22, 2026
Receptor
TAS2R46
Class
T2
Species
Homo sapiens
Ligand
Function
TANGERETIN
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
TANGERETIN L62 2.57x57 TM2 Van der Waals
TANGERETIN N65 2.60x60 TM2 polar (hydrogen bond)
TANGERETIN Y85 3.29x29 TM3 Van der Waals
TANGERETIN W88 3.32x32 TM3 aromatic (face-to-face)
TANGERETIN W88 3.32x32 TM3 hydrophobic
TANGERETIN L168 ECL2 Van der Waals
TANGERETIN R169 ECL2 hydrophobic
TANGERETIN S170 ECL2 Van der Waals
TANGERETIN A171 ECL2 Van der Waals
TANGERETIN M172 ECL2 Van der Waals
TANGERETIN N176 5.39x40 TM5 hydrophobic
TANGERETIN T180 5.43x44 TM5 Van der Waals
TANGERETIN E265 7.39x38 TM7 Van der Waals
TANGERETIN F269 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K I ICL1ECL1 P A F N ECL1ICL2 N F S N L I F L H L K R ICL2ECL2 I W T K E Y E G N M T W K I K L R S A M Y L S ECL2ICL3 K G S Q ICL3ECL3 L E N ECL3N-term M N-termC-term K G E K P S S S C-term I T F L P I I F S I L I V V T F V I G N F A N G F I A L V N S I E W F K R Q S F A D Q I L T A L A V S R V G L L W V L V L N W Y A T E L N S I E V R I T A Y N V W A V I N H F S N W L A T S L S I F Y L L K I A R V K S V V L V I L L G P L L F L V C H L F V I N M N Q I N T T V T I L A N L V P F T L T L I S F L L L I C S L C K H L K K M Q L H G D P S M K V H I K A L Q T V T S F L L L C A I Y F L S I I M S V W S F E S K P V F M F C E A I A F S Y P S T H P F I L I W G N K K F L S V R Y L K Q T V L W H W V
Helix box plot — Download: PNG | SVG G N A F N G I V F T V V I L I S F I I P 1 T A L A V S R V G L L W V L V L N W Y A 2 S T A L W N S F H N I V A W V N Y A T I 3 V L V I L L G P L L F L V C H L F V I N 4 F S I L T L T F P V L N A L I T V T T N 5 V T S F L L L C A I Y F L S I I M S V W 6 F P H T S P Y S F A I A E C F M F V P 7

GPCRdb(A)
GPCRdb(A)
TAS2R46
TM2
2x57 2.57x57 L62
2x60 2.60x60 N65
TM3
3x29 3.29x29 Y85
3x32 3.32x32 W88
TM5
5x40 5.39x40 N176
5x44 5.43x44 T180
TM7
7x38 7.39x38 E265
7x42 7.43x42 F269