PDB
9W0W
Resolution
3.2 Å
Released
April 22, 2026
Receptor
TAS2R46
Class
T2
Species
Homo sapiens
Ligand
Function
strychnine
Agonist
Reference
10.1038/S41594-026-01786-8

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
strychnine L62 2.57x57 TM2 hydrophobic
strychnine N65 2.60x60 TM2 hydrophobic
strychnine A84 3.28x28 TM3 Van der Waals
strychnine Y85 3.29x29 TM3 hydrophobic
strychnine Y85 3.29x29 TM3 aromatic (edge-to-face)
strychnine W88 3.32x32 TM3 hydrophobic
strychnine W88 3.32x32 TM3 aromatic (face-to-face)
strychnine I245 6.52x52 TM6 hydrophobic
strychnine S248 6.55x55 TM6 Van der Waals
strychnine V249 6.56x56 TM6 Van der Waals
strychnine F261 7.35x34 TM7 Van der Waals
strychnine E265 7.39x38 TM7 polar (charge-charge)
strychnine E265 7.39x38 TM7 polar (hydrogen bond)

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 K I ICL1ECL1 P A F N ECL1ICL2 N F S N L I F L H L K R ICL2ECL2 I W T K E Y E G N M T W K I K L R S A M Y L S ECL2ICL3 K G S Q ICL3ECL3 L E N ECL3N-term M N-termC-term K G E K P S S S C-term I T F L P I I F S I L I V V T F V I G N F A N G F I A L V N S I E W F K R Q S F A D Q I L T A L A V S R V G L L W V L V L N W Y A T E L N S I E V R I T A Y N V W A V I N H F S N W L A T S L S I F Y L L K I A R V K S V V L V I L L G P L L F L V C H L F V I N M N Q I N T T V T I L A N L V P F T L T L I S F L L L I C S L C K H L K K M Q L H G D P S M K V H I K A L Q T V T S F L L L C A I Y F L S I I M S V W S F E S K P V F M F C E A I A F S Y P S T H P F I L I W G N K K F L S V R Y L K Q T V L W H W V
Helix box plot — Download: PNG | SVG G N A F N G I V F T V V I L I S F I I P 1 T A L A V S R V G L L W V L V L N W Y A 2 S T A L W N S F H N I V A W V N Y A T I 3 V L V I L L G P L L F L V C H L F V I N 4 F S I L T L T F P V L N A L I T V T T N 5 V T S F L L L C A I Y F L S I I M S V W 6 F P H T S P Y S F A I A E C F M F V P 7

GPCRdb(A)
GPCRdb(A)
TAS2R46
TM2
2x57 2.57x57 L62
2x60 2.60x60 N65
TM3
3x28 3.28x28 A84
3x29 3.29x29 Y85
3x32 3.32x32 W88
TM6
6x52 6.52x52 I245
6x55 6.55x55 S248
6x56 6.56x56 V249
TM7
7x34 7.35x34 F261
7x38 7.39x38 E265