PDB
9W2H
Resolution
3.1 Å
Released
June 17, 2026
Receptor
NK2
Class
A
Species
Homo sapiens
Ligand
EB1002
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
EB1002 F26 N-term hydrophobic
EB1002 N86 2.57x57 TM2 Van der Waals
EB1002 N86 2.57x57 TM2 polar (hydrogen bond)
EB1002 N86 2.57x57 TM2 polar (hydrogen bond)
EB1002 N90 2.61x61 TM2 polar (hydrogen bond)
EB1002 Y93 2.64x64 TM2 Van der Waals
EB1002 Y93 2.64x64 TM2 hydrophobic
EB1002 A94 2.65x65 TM2 Van der Waals
EB1002 N97 ECL1 Van der Waals
EB1002 N110 3.29x29 TM3 Van der Waals
EB1002 I114 3.33x33 TM3 Van der Waals
EB1002 I114 3.33x33 TM3 hydrophobic
EB1002 Q166 4.60x61 TM4 Van der Waals
EB1002 D175 ECL2 Van der Waals
EB1002 Q176 ECL2 polar (hydrogen bond)
EB1002 A178 ECL2 Van der Waals
EB1002 K180 ECL2 polar (charge-assisted hydrogen bond)
EB1002 C181 45.50x50 ECL2 Van der Waals
EB1002 V182 45.51x51 ECL2 Van der Waals
EB1002 V182 45.51x51 ECL2 hydrophobic
EB1002 H198 5.39x40 TM5 Van der Waals
EB1002 Y266 6.51x51 TM6 polar (hydrogen bond)
EB1002 Y269 6.54x54 TM6 Van der Waals
EB1002 Y269 6.54x54 TM6 polar (hydrogen bond)
EB1002 F270 6.55x55 TM6 Van der Waals
EB1002 F270 6.55x55 TM6 hydrophobic
EB1002 Y280 ECL3 polar (hydrogen bond with backbone)
EB1002 Y280 ECL3 Van der Waals
EB1002 C281 ECL3 polar (hydrogen bond)
EB1002 C281 ECL3 Van der Waals
EB1002 I285 7.31x30 TM7 hydrophobic
EB1002 Q286 7.32x31 TM7 Van der Waals
EB1002 Y289 7.35x34 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 R R M R ICL1ECL1 I W Y F ECL1ICL2 P F Q P R L ICL2ECL2 T V T M D Q G A T K C V V A W P E D ECL2ICL3 Q A H G ICL3ECL3 E D I Y C H ECL3N-term M G T C D I V T E A N I S S G P E S N T T G I T A F S M N-termC-term R C C P W V T P T K E D K L E L T P T T S L S T R V N R C H T K E T L F M A G D T A P S E A T S G E A G R P Q D G S G L W F G Y G L L A P T K T H V E I C-term P S W Q L A L W A T A Y L A L V L V A V T G N A I V I W I I L A H T V T N Y F I V N L A L A D L C M A A F N A A F N F V Y A S H N G R A F C Y F Q N L F P I T A M F V S I Y S M T A I A A D R Y M A I V H S A P S T K A V I A G I W L V A L A L A S P Q C F Y S S G G K T L L L Y H L V V I A L I Y F L P L A V M F V A Y S V I G L T L W R R A V P G H A N L R H L Q A M K K F V K T M V L V V L T F A I C W L P Y H L Y F I L G S F Q K F I Q Q V Y L A L F W L A M S S T M Y N P I I Y C C L N H R F R L F R S G A F
Helix box plot — Download: PNG | SVG A N G T V A V L V L A L Y A T A W L A L 1 V N L A L A D L C M A A F N A A F N F V 2 A T M S Y I S V F M A T I P F L N Q F Y 3 T K A V I A G I W L V A L A L A S P Q 4 Y A V F M V A L P L F Y I L A I V V L H Y 5 V L V V L T F A I C W L P Y H L Y F I L 6 I P N Y M T S S M A L W F L A L Y V Q 7

GPCRdb(A)
GPCRdb(A)
NK2 receptor
TM2
2x57 2.57x57 N86
2x61 2.61x61 N90
2x64 2.64x64 Y93
2x65 2.65x65 A94
TM3
3x29 3.29x29 N110
3x33 3.33x33 I114
TM4
4x61 4.60x61 Q166
ECL2
45x50 45.50x50 C181
45x51 45.51x51 V182
TM5
5x40 5.39x40 H198
TM6
6x51 6.51x51 Y266
6x54 6.54x54 Y269
6x55 6.55x55 F270
TM7
7x30 7.31x30 I285
7x31 7.32x31 Q286
7x34 7.35x34 Y289