PDB
9W32
Resolution
2.6 Å
Released
Jan. 21, 2026
Receptor
SST5
Class
A
Species
Homo sapiens
Ligand
CHEMBL4063587
Function
Antagonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4063587 Y47 1.39x39 TM1 polar (hydrogen bond)
CHEMBL4063587 L96 2.60x60 TM2 hydrophobic
CHEMBL4063587 L96 2.60x60 TM2 Van der Waals
CHEMBL4063587 Q99 2.63x63 TM2 Van der Waals
CHEMBL4063587 Q99 2.63x63 TM2 polar (hydrogen bond)
CHEMBL4063587 N100 2.64x64 TM2 polar (hydrogen bond)
CHEMBL4063587 N100 2.64x64 TM2 polar (hydrogen bond)
CHEMBL4063587 M116 3.29x29 TM3 hydrophobic
CHEMBL4063587 M116 3.29x29 TM3 Van der Waals
CHEMBL4063587 D119 3.32x32 TM3 Van der Waals
CHEMBL4063587 G120 3.33x33 TM3 Van der Waals
CHEMBL4063587 L174 4.60x61 TM4 Van der Waals
CHEMBL4063587 L174 4.60x61 TM4 hydrophobic
CHEMBL4063587 N187 45.51x51 ECL2 polar (hydrogen bond)
CHEMBL4063587 N187 45.51x51 ECL2 polar (hydrogen bond)
CHEMBL4063587 F201 5.38x39 TM5 Van der Waals
CHEMBL4063587 F201 5.38x39 TM5 hydrophobic
CHEMBL4063587 I202 5.39x40 TM5 Van der Waals
CHEMBL4063587 I202 5.39x40 TM5 hydrophobic
CHEMBL4063587 T205 5.42x43 TM5 Van der Waals
CHEMBL4063587 A206 5.43x44 TM5 Van der Waals
CHEMBL4063587 W261 6.48x48 TM6 hydrophobic
CHEMBL4063587 F264 6.51x51 TM6 aromatic (edge-to-face)
CHEMBL4063587 F264 6.51x51 TM6 Van der Waals
CHEMBL4063587 F265 6.52x52 TM6 Van der Waals
CHEMBL4063587 F265 6.52x52 TM6 hydrophobic
CHEMBL4063587 N268 6.55x55 TM6 Van der Waals
CHEMBL4063587 Y286 7.35x34 TM7 Van der Waals
CHEMBL4063587 Y286 7.35x34 TM7 hydrophobic
CHEMBL4063587 V290 7.39x38 TM7 Van der Waals
CHEMBL4063587 V290 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 A K M K ICL1ECL1 S F W P F ECL1ICL2 P L S S A R W R ICL2ECL2 D V Q E G G T C N A S W P E ECL2ICL3 G C V R ICL3ECL3 A L P Q E P A ECL3N-term M E P L F P A S T P S W N A S S P G A A S G G G D N R T L V G P A P S A N-termC-term L R K G S G A K D A D A T E P R P D R I R Q Q Q E A T P P A H R A A A N G L M Q T S K L C-term G A R A V L V P V L Y L L V C A A G L G G N T L V I Y V V L R F T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H R P R V A K L A S A A A W V L S L C M S L P L L V F A P V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R A A G V R V R R S E R K V T R M V L V V V L V F A G C W L P F F T V N I V N L A V S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F Q K F R Q S V L C
Helix box plot — Download: PNG | SVG T N G G L G A A C V L L Y L V P V L V A 1 L N L A V A D V L Y M L G L P F L A T Q 2 V T L C F V S T F Q N V G D L T M V L R 3 A K L A S A A A W V L S L C M S L P L 4 Y C L C I V L L P A F F G L V A T Y I I F 5 L V V V L V F A G C W L P F F T V N I V 6 V P N A C S N A Y S L I V V F F Y L G 7

GPCRdb(A)
GPCRdb(A)
SST5 receptor
TM1
1x39 1.39x39 Y47
TM2
2x60 2.60x60 L96
2x63 2.63x63 Q99
2x64 2.64x64 N100
TM3
3x29 3.29x29 M116
3x32 3.32x32 D119
3x33 3.33x33 G120
TM4
4x61 4.60x61 L174
ECL2
45x51 45.51x51 N187
TM5
5x39 5.38x39 F201
5x40 5.39x40 I202
5x43 5.42x43 T205
5x44 5.43x44 A206
TM6
6x48 6.48x48 W261
6x51 6.51x51 F264
6x52 6.52x52 F265
6x55 6.55x55 N268
TM7
7x34 7.35x34 Y286
7x38 7.39x38 V290