PDB
9W49
Resolution
2.9 Å
Released
Nov. 19, 2025
Receptor
κ
Class
A
Species
Homo sapiens
Ligand
Function
U50488
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
U50488 V108 2.53x53 TM2 hydrophobic
U50488 F114 2.59x59 TM2 hydrophobic
U50488 Q115 2.60x60 TM2 hydrophobic
U50488 V118 2.63x63 TM2 hydrophobic
U50488 W124 23.50x50 ECL1 hydrophobic
U50488 V134 3.28x28 TM3 hydrophobic
U50488 D138 3.32x32 TM3 polar (charge-charge)
U50488 Y139 3.33x33 TM3 hydrophobic
U50488 M142 3.36x36 TM3 hydrophobic
U50488 W287 6.48x48 TM6 hydrophobic
U50488 Y312 7.35x34 TM7 Van der Waals
U50488 I316 7.39x38 TM7 hydrophobic
U50488 Y320 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
Helix box plot — Download: PNG | SVG S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7

GPCRdb(A)
GPCRdb(A)
κ receptor
TM2
2x53 2.53x53 V108
2x59 2.59x59 F114
2x60 2.60x60 Q115
2x63 2.63x63 V118
ECL1
23x50 23.50x50 W124
TM3
3x28 3.28x28 V134
3x32 3.32x32 D138
3x33 3.33x33 Y139
3x36 3.36x36 M142
TM6
6x48 6.48x48 W287
TM7
7x34 7.35x34 Y312
7x38 7.39x38 I316
7x42 7.43x42 Y320