PDB
9WG4
Resolution
3.3 Å
Released
June 17, 2026
Receptor
OR52E8
Class
O1
Species
Homo sapiens
Ligand
Function
(3R)-3-Hydroxy-3-methylhexanoic acid
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
(3R)-3-Hydroxy-3-methylhexanoic acid H107 3.33x33 TM3 hydrophobic
(3R)-3-Hydroxy-3-methylhexanoic acid T110 3.36x36 TM3 Van der Waals
(3R)-3-Hydroxy-3-methylhexanoic acid L161 4.60x60 TM4 Van der Waals
(3R)-3-Hydroxy-3-methylhexanoic acid H183 45.52x52 ECL2 polar (hydrogen bond)
(3R)-3-Hydroxy-3-methylhexanoic acid G201 5.39x39 TM5 Van der Waals
(3R)-3-Hydroxy-3-methylhexanoic acid N204 5.42x42 TM5 Van der Waals
(3R)-3-Hydroxy-3-methylhexanoic acid I205 5.43x43 TM5 hydrophobic
(3R)-3-Hydroxy-3-methylhexanoic acid F261 6.55x55 TM6 hydrophobic
(3R)-3-Hydroxy-3-methylhexanoic acid R265 6.59x59 TM6 polar (charge-charge)
(3R)-3-Hydroxy-3-methylhexanoic acid R265 6.59x59 TM6 polar (hydrogen bond)

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ICL1 Q S L H ICL1ECL1 T K E I ECL1ICL2 P L R Y T M I L ICL2ECL2 L P F C G H R I I P H T Y C E H M G I A R L A C A S ECL2ICL3 L P ICL3ECL3 H N I ECL3N-term M S T S N H T Q F H P S S F L L L G I P G N-termC-term T N H C-term L E D V H I W I G V P F F F V Y L V A L L G N T A L L F V I Q T E E P M Y Y F L A M L D S I D L G L S T A T I P K M L G I F W F N S F G G C L S H M F F I H F F T A M E S I V L V A M A F D R Y I A I C K T S K I I S L I A G I A V L R S L Y M V V P L V F L L L R I K V N I R F G L G N I S L L L L D V I L I I L S Y V R I L Y A V F C S W E A R L K A L N T C G S H I G V I L A F F T P A F F S F L T H R F G P Q Y I H I I L A N L Y V V V P P A L N P V I Y G V R T K Q V L R I R E R I F L K
Helix box plot — Download: PNG | SVG T N G L L A V L Y V F F F P V G I W I H 1 A M L D S I D L G L S T A T I P K M L G 2 A V L V I S E M A T F F H I F F M H S L 3 I S L I A G I A V L R S L Y M V V P L V 4 Y S L I I L I V D L L L L S I N G L G F 5 G S H I G V I L A F F T P A F F S F L T 6 V P N L A P P V V V Y L N A L I I H I 7

GPCRdb(A)
GPCRdb(A)
OR52E8
TM3
3x33 3.33x33 H107
3x36 3.36x36 T110
TM4
4x60 4.60x60 L161
ECL2
45x52 45.52x52 H183
TM5
5x39 5.39x39 F200
5x42 5.42x42 G203
5x43 5.43x43 N204
TM6
6x55 6.55x55 F260
6x59 6.59x59 R264