PDB
9XHI
Resolution
3.2 Å
Released
April 22, 2026
Receptor
CCR7
Class
A
Species
Homo sapiens
Ligand
C-C motif chemokine 21
Function
Agonist
Reference
10.1073/PNAS.2533975123

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Ligand Amino Acid Generic Number Segment Interaction Type
C-C motif chemokine 21 V39 N-term hydrophobic
C-C motif chemokine 21 Y41 N-term aromatic (face-to-face)
C-C motif chemokine 21 L43 N-term hydrophobic
C-C motif chemokine 21 F44 N-term hydrophobic
C-C motif chemokine 21 E45 N-term polar (hydrogen bond with backbone)
C-C motif chemokine 21 E45 N-term Van der Waals
C-C motif chemokine 21 S46 N-term polar (hydrogen bond)
C-C motif chemokine 21 S46 N-term Van der Waals
C-C motif chemokine 21 L47 N-term Van der Waals
C-C motif chemokine 21 L47 N-term polar (hydrogen bond with backbone)
C-C motif chemokine 21 C48 N-term Van der Waals
C-C motif chemokine 21 S49 N-term Van der Waals
C-C motif chemokine 21 K50 N-term Van der Waals
C-C motif chemokine 21 K50 N-term polar (hydrogen bond with backbone)
C-C motif chemokine 21 V53 N-term Van der Waals
C-C motif chemokine 21 V53 N-term hydrophobic
C-C motif chemokine 21 R54 N-term polar (charge-assisted hydrogen bond)
C-C motif chemokine 21 K57 1.31x31 TM1 Van der Waals
C-C motif chemokine 21 Q200 ECL2 polar (hydrogen bond)
C-C motif chemokine 21 Q200 ECL2 polar (hydrogen bond)
C-C motif chemokine 21 Q200 ECL2 polar (hydrogen bond)
C-C motif chemokine 21 R209 ECL2 polar (charge-assisted hydrogen bond)
C-C motif chemokine 21 L212 45.52x52 ECL2 polar (hydrogen bond with backbone)
C-C motif chemokine 21 L212 45.52x52 ECL2 Van der Waals
C-C motif chemokine 21 I213 ECL2 Van der Waals
C-C motif chemokine 21 I213 ECL2 hydrophobic
C-C motif chemokine 21 T214 ECL2 Van der Waals
C-C motif chemokine 21 T214 ECL2 polar (hydrogen bond with backbone)
C-C motif chemokine 21 V217 5.32x33 TM5 Van der Waals
C-C motif chemokine 21 F220 5.35x36 TM5 Van der Waals
C-C motif chemokine 21 F220 5.35x36 TM5 hydrophobic
C-C motif chemokine 21 Q286 6.58x58 TM6 polar (hydrogen bond)
C-C motif chemokine 21 N290 6.62x62 TM6 polar (hydrogen bond)
C-C motif chemokine 21 N290 6.62x62 TM6 polar (hydrogen bond)
C-C motif chemokine 21 S295 ECL3 Van der Waals
C-C motif chemokine 21 S296 ECL3 Van der Waals
C-C motif chemokine 21 C298 7.25x24 TM7 Van der Waals
C-C motif chemokine 21 N305 7.32x31 TM7 polar (hydrogen bond)
C-C motif chemokine 21 N305 7.32x31 TM7 Van der Waals
C-C motif chemokine 21 Y308 7.35x34 TM7 polar (hydrogen bond)
C-C motif chemokine 21 Y308 7.35x34 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K R L K ICL1ECL1 S W V F ECL1ICL2 A V S A H R H R A R ICL2ECL2 D L Q R S S S E Q A M R C S L I T E H V ECL2ICL3 R N ICL3ECL3 T S S ECL3N-term M D L G K P M K S V L V V A L L V I F Q V C L C Q D E V T D D Y I G D N T T V D Y T L F E S L C S K K D V R N-termC-term D L G C L S Q E Q L R Q W S S C R H I R R S S M S V E A E T T T T F S P C-term N F K A W F L P I M Y S I I C F V G L L G N G L V V L T Y I Y F T M T D T Y L L N L A V A D I L F L L T L P F W A Y S A A K G V H F C K L I F A I Y K M S F F S G M L L L L C I S I D R Y V A I V Q V L L I S K L S C V G I W I L A T V L S I P E L L Y S E A F I T I Q V A Q M V I G F L V P L L A M S F C Y L V I I R T L L Q A F E R N K A I K V I I A V V V V F I V F Q L P Y N G V V L A Q T V A N F N I T C E L S K Q L N I A Y D V T Y S L A C V R C C V N P F L Y A F I G V K L F K F R N D L F K
Helix box plot — Download: PNG | SVG G N G L L G V F C I I S Y M I P L F W A 1 L N L A V A D I L F L L T L P F W A Y S 2 C L L L L M G S F F S M K Y I A F I L K 3 S K L S C V G I W I L A T V L S I P E 4 Y C F S M A L L P V L F G I V M Q A V Q I 5 I A V V V V F I V F Q L P Y N G V V L A 6 F P N V C C R V C A L S Y T V D Y A I 7

GPCRdb(A)
GPCRdb(A)
CCR7
TM1
1x31 1.31x31 K57
ECL2
45x52 45.52x52 L212
TM5
5x36 5.35x36 F220
TM6
6x58 6.58x58 Q286
6x62 6.62x62 N290
TM7
7x24 7.25x24 C298
7x31 7.32x31 N305
7x34 7.35x34 Y308