PDB
9XJW
Resolution
2.5 Å
Released
May 27, 2026
Receptor
GPR119
Class
A
Species
Homo sapiens
Ligand
Function
AS1269574
Agonist (partial)
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
AS1269574 T86 3.33x33 TM3 Van der Waals
AS1269574 A89 3.36x36 TM3 Van der Waals
AS1269574 A90 3.37x37 TM3 Van der Waals
AS1269574 V93 3.40x40 TM3 hydrophobic
AS1269574 L94 3.41x41 TM3 hydrophobic
AS1269574 I136 4.56x56 TM4 hydrophobic
AS1269574 F157 45.52x52 ECL2 Van der Waals
AS1269574 L169 5.43x44 TM5 hydrophobic
AS1269574 G173 5.47x47 TM5 Van der Waals
AS1269574 F174 5.48x48 TM5 hydrophobic
AS1269574 W238 6.48x48 TM6 aromatic (edge-to-face)
AS1269574 W238 6.48x48 TM6 hydrophobic
AS1269574 L242 6.52x52 TM6 hydrophobic
AS1269574 W265 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 I H K N D ICL1ECL1 S P S ECL1ICL2 P F R Y L K I M ICL2ECL2 P M F Q Q T A Y K G Q C S F F A V ECL2ICL3 A M A G G Y ICL3ECL3 Q E C H L ECL3C-term G V K K V L T S F L L F L S A R N C G P E R P R E S S C H I V T I S S S E F D G C-term M E S S F S F G V I L A V L A S L I I A T N T L V A V A V L L L G V S L C F T L N L A V A D T L I G V A I S G L L T D Q L S R P T Q K T L C S L R M A F V T S S A A A S V L T V M L I T F D R Y L A I K Q S G F V A G A C I A G L W L V S Y L I G F L P L G I F H P H F V L T L S C V G F F P A M L L F V F F Y C D M L K I A S M H S Q Q I R K M E H A G R S P R T P S D F K A L R T V S V L I G S F A L S W T P F L I T G I V Q V A C Y L V L E R Y L W L L G V G N S L L N P L I Y A Y W Q K E L Y H V R L Q M A L
Helix box plot — Download: PNG | SVG T N T A I I L S A L V A L I V G F S F S 1 L N L A V A D T L I G V A I S G L L T D 2 L M V T L V S A A A S S T V F A M R L S 3 A G A C I A G L W L V S Y L I G F L P L 4 F F V F L L M A P F F G V C S L T L V F H 5 S V L I G S F A L S W T P F L I T G I V 6 L P N L L S N G V G L L W L Y R E L V 7

GPCRdb(A)
GPCRdb(A)
GPR119
TM3
3x33 3.33x33 T86
3x36 3.36x36 A89
3x37 3.37x37 A90
3x40 3.40x40 V93
3x41 3.41x41 L94
TM4
4x56 4.56x56 I136
ECL2
45x52 45.52x52 F157
TM5
5x44 5.43x44 L169
5x47 5.47x47 G173
5x48 5.48x48 F174
TM6
6x48 6.48x48 W238
6x52 6.52x52 L242
TM7
7x38 7.39x38 W265